Protein profile

KP13_00248

Protein hokA

Genome: KpKP13

Gene: AHE42160.1 hokA Structure source: AlphaFold + ColabFold UniProt A0A0H3GX76
Export view
Amino acids 50
Annotations 2
Features 12
PDB binders 0
Druggability 0.336

Overview

Basic information about this protein and its source genome.

Accession
KP13_00248
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42160.1 hokA
Status
annotated
Amino acids
50
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
66.0
DEG E-value
4.84e-22
Localization
Periplasmic
ColabFold pLDDT
70.49

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.336
Structure A0A0H3GX76
Pocket Pocket 8
P2Rank
Structure A0A0H3GX76
Pocket No pockets
ColabFold model
FPocket 0.938 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 29 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
10 29 ProSitePatterns PS00556 Hok/gef family cell toxic proteins signature.
10 29 InterPro IPR018084 Hok/gef cell toxic protein, conserved site
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 50 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 23 PRINTS PR00281 Hok/Gef cell toxic protein family signature
5 23 InterPro IPR000021 Hok/gef cell toxic protein
25 47 PRINTS PR00281 Hok/Gef cell toxic protein family signature
25 47 InterPro IPR000021 Hok/gef cell toxic protein
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 46 Pfam PF01848 Hok/gef family
5 46 InterPro IPR000021 Hok/gef cell toxic protein
6 24 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX76
AlphaFold — — full sequence — Viewing
ColabFold KP13_00248
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.336
2 0.264
9 0.227