Protein profile

KP13_00251

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE42163.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUM3
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Amino acids 96
Annotations 1
Features 13
PDB binders 0
Druggability 0.124

Overview

Basic information about this protein and its source genome.

Accession
KP13_00251
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42163.1
Status
annotated
Amino acids
96
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
75.46

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.124
Structure A0A0H3GUM3
Pocket Pocket 2
P2Rank
Structure A0A0H3GUM3
Pocket No pockets
ColabFold model
FPocket 0.029 · Pocket 6
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 70 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
40 81 CDD cd00093 HTH_XRE
40 81 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
19 93 PANTHER PTHR36511 MERR FAMILY BACTERIAL REGULATORY PROTEIN
39 82 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
39 82 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
39 80 Pfam PF01381 Helix-turn-helix
39 80 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
37 91 SMART SM00530 mbf_short4
37 91 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
28 94 Gene3D G3DSA:1.10.260.40 -
28 94 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
38 91 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
38 91 InterPro IPR001387 Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GUM3 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUM3
AlphaFold — — full sequence — Viewing
ColabFold KP13_00251
ColabFold — — full sequence — Loaded