Protein profile

KP13_00269

Dipeptide transport system permease protein dppB

Genome: KpKP13

Gene: AHE42180.1 dppB Structure source: AlphaFold + ColabFold UniProt A0A0H3GUJ7
Export view
Amino acids 339
Annotations 4
Features 32
PDB binders 0
Druggability 0.851

Overview

Basic information about this protein and its source genome.

Accession
KP13_00269
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42180.1 dppB
Status
annotated
Amino acids
339
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.851
Structure A0A0H3GUJ7
Pocket Pocket 10
P2Rank 0.218
Structure A0A0H3GUJ7
Pocket Pocket 1
ColabFold model
FPocket 0.583 · Pocket 6
P2Rank 0.49 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 151 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
258 280 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
114 336 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
114 336 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 77 Pfam PF19300 Binding-prot-dependent transport system membrane comp, N-term
1 77 InterPro IPR045621 ABC transporter type 1, GsiC-like, N-terminal domain
87 330 Gene3D G3DSA:1.10.3720.10 -
87 330 InterPro IPR035906 MetI-like superfamily
309 331 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
222 258 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
100 123 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 8 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
135 158 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
332 339 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
31 99 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
201 221 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
259 285 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 338 PANTHER PTHR43163 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
96 326 CDD cd06261 TM_PBP2
96 326 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
134 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
202 221 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
124 134 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
305 331 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
89 322 SUPERFAMILY SSF161098 MetI-like
89 322 InterPro IPR035906 MetI-like superfamily
286 304 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
9 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
99 121 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
159 200 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
96 328 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
96 328 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUJ7
AlphaFold — — full sequence — Viewing
ColabFold KP13_00269
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.851
7 0.328

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.93 0.155
2 3.82 0.148
3 1.64 0.027
4 1.62 0.026
5 1.06 0.007