Protein profile

KP13_00270

Dipeptide transport system permease protein dppC

Genome: KpKP13

Gene: dppC AHE42181.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4C3
Export view
Amino acids 300
Annotations 5
Features 30
PDB binders 0
Druggability 0.987

Overview

Basic information about this protein and its source genome.

Accession
KP13_00270
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
dppC AHE42181.1
Status
annotated
Amino acids
300
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
52.128
DEG E-value
1.08e-107
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.987
Structure A0A0H3H4C3
Pocket Pocket 1
P2Rank 0.463
Structure A0A0H3H4C3
Pocket Pocket 1
ColabFold model
FPocket 0.911 · Pocket 3
P2Rank 0.416 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 155 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
147 173 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 280 SUPERFAMILY SSF161098 MetI-like
93 280 InterPro IPR035906 MetI-like superfamily
210 232 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 31 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
100 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
98 287 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
98 287 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
174 214 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
88 295 FunFam G3DSA:1.10.3720.10:FF:000007 Dipeptide ABC transporter permease DppC
88 295 Gene3D G3DSA:1.10.3720.10 -
88 295 InterPro IPR035906 MetI-like superfamily
116 299 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
116 299 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
128 146 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17 69 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
17 69 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain
54 99 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
264 287 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
265 287 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
16 298 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
140 162 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
114 290 CDD cd06261 TM_PBP2
114 290 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
215 244 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
288 300 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
32 53 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
245 263 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4C3
AlphaFold — — full sequence — Viewing
ColabFold KP13_00270
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.987

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.05 0.365
2 4.83 0.215
3 2.72 0.082
4 1.3 0.014