Protein profile

KP13_00277

Cyclic di-GMP-binding protein

Genome: KpKP13

Gene: bcsB AHE42188.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYN3
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Amino acids 813
Annotations 4
Features 31
PDB binders 0
Druggability 0.511

Overview

Basic information about this protein and its source genome.

Accession
KP13_00277
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
bcsB AHE42188.1
Status
annotated
Amino acids
813
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006011 The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
82.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.511
Structure A0A0H3GYN3
Pocket Pocket 10
P2Rank 0.533
Structure A0A0H3GYN3
Pocket Pocket 1
ColabFold model
FPocket 0.905 · Pocket 51
P2Rank 0.594 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 33 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006011 The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
117 807 PANTHER PTHR39083 CYCLIC DI-GMP-BINDING PROTEIN
117 807 InterPro IPR018513 Cellulose synthase BcsB, bacterial
15 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
4 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
777 799 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
178 201 PRINTS PR01440 Cellulose synthase subunit B signature
178 201 InterPro IPR003920 Cellulose synthase, subunit B
261 284 PRINTS PR01440 Cellulose synthase subunit B signature
261 284 InterPro IPR003920 Cellulose synthase, subunit B
552 571 PRINTS PR01440 Cellulose synthase subunit B signature
552 571 InterPro IPR003920 Cellulose synthase, subunit B
504 523 PRINTS PR01440 Cellulose synthase subunit B signature
504 523 InterPro IPR003920 Cellulose synthase, subunit B
130 151 PRINTS PR01440 Cellulose synthase subunit B signature
130 151 InterPro IPR003920 Cellulose synthase, subunit B
752 772 PRINTS PR01440 Cellulose synthase subunit B signature
752 772 InterPro IPR003920 Cellulose synthase, subunit B
423 444 PRINTS PR01440 Cellulose synthase subunit B signature
423 444 InterPro IPR003920 Cellulose synthase, subunit B
12 85 MobiDBLite mobidb-lite consensus disorder prediction
1 20 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
105 711 Pfam PF03170 Bacterial cellulose synthase subunit
105 711 InterPro IPR018513 Cellulose synthase BcsB, bacterial
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
778 799 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
103 230 Gene3D G3DSA:2.60.120.260 -
389 544 Gene3D G3DSA:2.60.120.260 -
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
22 777 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
800 813 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYN3
AlphaFold — — full sequence — Viewing
ColabFold KP13_00277
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
57 0.073
1 0.013
3 0.008
51 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.57 0.533
2 7.44 0.328
3 7.16 0.312
4 7.06 0.306
5 3.82 0.12