Protein profile

KP13_00278

Cellulose synthase operon protein C

Genome: KpKP13

Gene: bcsC AHE42189.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZW7

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Amino acids 1350

Annotations 5

Features 44

PDB binders 4

Druggability 0.793

Overview

Basic information about this protein and its source genome.

Accession: KP13_00278
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: bcsC AHE42189.1
Status: annotated
Amino acids: 1350
Structure source: AlphaFold + ColabFold

GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515 Binding to a protein. GO:0006011 The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: Unknown
ColabFold pLDDT: 84.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.793

Structure A0A0H3GZW7

Pocket Pocket 67

P2Rank 0.772

Structure A0A0H3GZW7

Pocket Pocket 1

ColabFold model

FPocket 0.848 · Pocket 128

P2Rank 0.716 · Pocket 1

Core conservation Accessory gene

Roary accessory

CoreCruncher accessory

Gut microbiome 32 / 4744 genomes with a hit

Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

MKRKIIITMKNTRRLTTFCLTGALTLAASGGALAAGNDAALQALFAQANYWHEKSHDELAMESLQKVLSVDANNTQALYLMALWSQQGGDMQAAAQWRARLAKAAPDSPGLQDLDNAKKMSQVPQGQLSLARQQARGGNIPGALATWRSMFNGNTPPAGLAAEYYLTMASDKSLYPQAISELRQYVAQHPQENAPRVALGKALTWREETRREGIALLEPMASGNKEADSGLRQALLWLGPQAGDEQYYDTWMQRHPQDSEVQNYFRERRSGQARGQGYANLNSGNTAAAKQQFEEVLQTNPQDADALAGMGYIAQRSGDYQAASQYLSRAADLGGDASATRRQQAADALFYGQLAQAQQAYKQGNISQALALSAPLAQQSGAQGASAKLFRADVLRHNKDLPQAEQTLRSLLNDDPQNAAARENLYYVLREQNKSAEAQAMLQTLPQSLRQKLQPRVVAGMPGDALRRQAQAQVSGGNPAGAIATLREGVARYPDDPWLRLDLARLLQKSGNGSEASSLMSAAYRPGASNSALYAAALFASENGAWQQAQTLLARIPGGSQTSDMRDLRQRVNYNLQLVTAENYLAQGNTIAASNTLRAMASTPPKAPADAGKLARLLAESGDLTTAVSLVRNNISSGVSGNAGDYADQIAVLNQAGLTGEAQNLISNPQLQASSTPTQLASIRNGYVINEADRLREQGNYAAAYDKLIRAMQSDPQNTDLMFAMARLYQSGKMNKEAGVVYDYLMTRDTPNQDARAGAIDVALSAGNNDRAEQLAGGLRQDNSPDRLLLLARVAEAQGHHQQAMTYLRSARGKLLGMQSTNSSETPTVGGVLAADNPFIGVSQTSAPTRTASAYGQYMPWQVAQSAAAPGSTLPGIQRTDLPVDTAQTRMLRQVDTMMESLQEKTGSWLQGGMDVRGRDGESGTSKLTELRTPLTWSSSPFGDSRFDFTVTPVSLNAGTASGDAWRRYGANPLANAVSNMVSTATSEQAAIASMTEAERTAYFASNPGAEALSGLGTLNAADFNPTTSSGMENLAKLGSYDAGQVASYLSSSSRKPNVDQTSGSTDSQKANGVELALALSGDDYRVDIGSTPLGQDLNTVVGGVKWSPKLTNYLSLILTGERRSLTDSLLSYVGLKDAYSGKTWGQVTKNGGTLQLSYDDGDAGFYVGGGGYSYLGQNVASNTSINANAGVYLRPYHDEYRQLQAGLSMSYMDYSKNLSYFTYGQGGYFSPQNYVSVSLPVSLTEKYDNWTMKLGGSVGYQSYSQDKSAYFPTNSEWQQTLETAVSNGFAKEAYYSATSKSGIGYTLRAGADYKVNKQMTLGGQIGYDTFGDYNESTAGLYIRYMLGDH

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005515 Binding to a protein.
GO:0006011 The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate.
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Sequence Features

Domain/signature hits from InterPro and related databases.

44 records

Show feature table

Start	End	DB	Term	Name
162	526	Gene3D	G3DSA:1.25.40.10	Tetratricopeptide repeat domain
162	526	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
391	742	SUPERFAMILY	SSF48452	TPR-like
391	742	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
32	127	Gene3D	G3DSA:1.25.40.10	Tetratricopeptide repeat domain
32	127	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
45	362	SUPERFAMILY	SSF48452	TPR-like
45	362	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
41	510	PANTHER	PTHR12558	CELL DIVISION CYCLE 16,23,27
35	1350	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
926	1347	Pfam	PF05420	Cellulose synthase operon protein C C-terminus (BCSC_C)
926	1347	InterPro	IPR008410	Cellulose synthase operon C, C-terminal
1	34	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
15	26	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
41	74	SMART	SM00028	tpr_5
41	74	InterPro	IPR019734	Tetratricopeptide repeat
385	418	SMART	SM00028	tpr_5
385	418	InterPro	IPR019734	Tetratricopeptide repeat
270	303	SMART	SM00028	tpr_5
270	303	InterPro	IPR019734	Tetratricopeptide repeat
463	496	SMART	SM00028	tpr_5
463	496	InterPro	IPR019734	Tetratricopeptide repeat
304	337	SMART	SM00028	tpr_5
304	337	InterPro	IPR019734	Tetratricopeptide repeat
785	818	SMART	SM00028	tpr_5
785	818	InterPro	IPR019734	Tetratricopeptide repeat
27	34	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	14	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
189	206	PRINTS	PR01441	Cellulose synthase subunit C signature
189	206	InterPro	IPR003921	Cellulose synthase, subunit C
159	171	PRINTS	PR01441	Cellulose synthase subunit C signature
159	171	InterPro	IPR003921	Cellulose synthase, subunit C
1212	1236	PRINTS	PR01441	Cellulose synthase subunit C signature
1212	1236	InterPro	IPR003921	Cellulose synthase, subunit C
496	516	PRINTS	PR01441	Cellulose synthase subunit C signature
496	516	InterPro	IPR003921	Cellulose synthase, subunit C
1252	1273	PRINTS	PR01441	Cellulose synthase subunit C signature
1252	1273	InterPro	IPR003921	Cellulose synthase, subunit C
1	34	Phobius	SIGNAL_PEPTIDE	Signal peptide region
527	822	Gene3D	G3DSA:1.25.40.10	Tetratricopeptide repeat domain
527	822	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
1	34	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
477	523	Pfam	PF14559	Tetratricopeptide repeat

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GZW7	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_00278	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
67				0.793
74				0.65

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	13.53	0.69
2	11.35	0.607
3	4.2	0.171
4	3.42	0.123
5	3.37	0.12

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
128				0.848
2				0.811
1				0.221

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	11.58	0.616
2	11.15	0.598
3	5.84	0.285
4	4.58	0.198
5	3.52	0.129

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
3PE	6TZK	P37650	748.1 Da LogP 12.06 TPSA 134.4	2 viol.	✓ Clean	`CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC…`
C8E	6TZK	P37650	306.4 Da LogP 2.41 TPSA 57.2	✓ Ro5	✓ Clean	`CCCCCCCCOCCOCCOCCOCCO`
LMT	6TZK	P37650	510.6 Da LogP -0.45 TPSA 178.5	3 viol.	✓ Clean	`CCCCCCCCCCCCO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1…`
PE5	6TZK	P37650	398.5 Da LogP 0.13 TPSA 94.1	✓ Ro5	✓ Clean	`CCOCCOCCOCCOCCOCCOCCOCCOCCO`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC100014200	1.000	494.7 Da LogP 4.02 TPSA 84.8	✓ Ro5	✓ Clean	`CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO`
ZINC100053689	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H]…`
ZINC100053691	1.000	496.6 Da LogP -0.84 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCCO[C@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H…`
ZINC100070166	1.000	290.4 Da LogP 3.17 TPSA 47.9	✓ Ro5	✓ Clean	`CCCCCCCCCCOCCOCCOCCO`
ZINC100310628	1.000	478.7 Da LogP 4.78 TPSA 75.6	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCO`
ZINC100365196	1.000	302.5 Da LogP 4.71 TPSA 38.7	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCCOCCOCCO`
ZINC101772322	1.000	434.7 Da LogP 4.76 TPSA 66.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCCOCCOCCOCCOCCOCCO`
ZINC102190506	1.000	467.5 Da LogP 4.25 TPSA 134.4	✓ Ro5	✓ Clean	`CCCCCCCC(=O)OC[C@H](CO[P@@](=O)(O)OCCN)OC(=O)CC…`
ZINC102190512	1.000	467.5 Da LogP 4.25 TPSA 134.4	✓ Ro5	✓ Clean	`CCCCCCCC(=O)OC[C@@H](CO[P@@](=O)(O)OCCN)OC(=O)C…`
ZINC103600921	1.000	466.7 Da LogP 3.24 TPSA 84.8	✓ Ro5	✓ Clean	`CCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO`
ZINC14880431	1.000	378.6 Da LogP 3.20 TPSA 66.4	✓ Ro5	✓ Clean	`CCCCCCCCCCOCCOCCOCCOCCOCCO`
ZINC1501015302	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H…`
ZINC16051619	1.000	350.5 Da LogP 2.42 TPSA 66.4	✓ Ro5	✓ Clean	`CCCCCCCCOCCOCCOCCOCCOCCO`
ZINC2039285652	1.000	454.5 Da LogP -2.01 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCO[C@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H](C…`
ZINC2039285653	1.000	454.5 Da LogP -2.01 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCO[C@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H](C…`
ZINC2039285654	1.000	454.5 Da LogP -2.01 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCO[C@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H](C…`
ZINC2039285655	1.000	454.5 Da LogP -2.01 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCO[C@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H](C…`
ZINC2053493146	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H]…`
ZINC2053493147	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H]…`
ZINC2053493148	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H]…`
ZINC2053493149	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H]…`
ZINC252695223	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H…`
ZINC252695224	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H…`
ZINC252695225	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H…`
ZINC252695226	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H…`
ZINC2584424	1.000	218.3 Da LogP 2.37 TPSA 38.7	✓ Ro5	✓ Clean	`CCCCCCCCOCCOCCO`
ZINC4521877	1.000	234.3 Da LogP 1.61 TPSA 47.9	✓ Ro5	✓ Clean	`CCCCCCOCCOCCOCCO`
ZINC5273610	1.000	322.4 Da LogP 1.64 TPSA 66.4	✓ Ro5	✓ Clean	`CCCCCCOCCOCCOCCOCCOCCO`
ZINC5650743	1.000	222.3 Da LogP 0.07 TPSA 57.2	✓ Ro5	✓ Clean	`CCOCCOCCOCCOCCO`
ZINC58538366	1.000	392.6 Da LogP 3.59 TPSA 66.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCOCCOCCOCCOCCOCCO`
ZINC58631420	1.000	422.6 Da LogP 3.22 TPSA 75.6	✓ Ro5	✓ Clean	`CCCCCCCCCCOCCOCCOCCOCCOCCOCCO`
ZINC58649715	1.000	496.6 Da LogP -0.84 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@…`
ZINC59441819	1.000	318.5 Da LogP 3.95 TPSA 47.9	✓ Ro5	✓ Clean	`CCCCCCCCCCCCOCCOCCOCCO`
ZINC59622400	1.000	274.4 Da LogP 3.93 TPSA 38.7	✓ Ro5	✓ Clean	`CCCCCCCCCCCCOCCOCCO`
ZINC6403917	1.000	354.4 Da LogP 0.11 TPSA 84.8	✓ Ro5	✓ Clean	`CCOCCOCCOCCOCCOCCOCCOCCO`
ZINC66157001	1.000	468.5 Da LogP -1.62 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H]…`
ZINC70669940	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O[C@H]2O[C@…`
ZINC70669941	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O[C@H]2O[C@…`
ZINC70669942	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O[C@H]2O[C@…`
ZINC70669943	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O[C@H]2O[C@…`
ZINC71788551	1.000	334.5 Da LogP 3.19 TPSA 57.2	✓ Ro5	✓ Clean	`CCCCCCCCCCOCCOCCOCCOCCO`
ZINC71788564	1.000	262.4 Da LogP 2.39 TPSA 47.9	✓ Ro5	✓ Clean	`CCCCCCCCOCCOCCOCCO`
ZINC77311968	1.000	454.5 Da LogP -2.01 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H]…`
ZINC8214594	1.000	362.6 Da LogP 3.97 TPSA 57.2	✓ Ro5	✓ Clean	`CCCCCCCCCCCCOCCOCCOCCOCCO`
ZINC83433913	1.000	426.5 Da LogP -2.79 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO…`
ZINC85482724	1.000	482.6 Da LogP -1.23 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H…`
ZINC86002923	1.000	426.5 Da LogP -2.79 TPSA 178.5	2 viol.	✓ Clean	`CCCCCCO[C@@H]1O[C@H](CO)[C@H](O[C@H]2O[C@H](CO)…`
ZINC88260008	1.000	390.6 Da LogP 4.75 TPSA 57.2	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCCOCCOCCOCCOCCO`
ZINC95784968	1.000	450.7 Da LogP 4.00 TPSA 75.6	✓ Ro5	✓ Clean	`CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCO`
ZINC95863931	1.000	464.7 Da LogP 4.39 TPSA 75.6	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCO`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.