Protein profile

KP13_00287

Cyclic di-GMP-binding protein

Genome: KpKP13

Gene: AHE42198.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYM8
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Amino acids 781
Annotations 4
Features 28
PDB binders 0
Druggability 0.64

Overview

Basic information about this protein and its source genome.

Accession
KP13_00287
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42198.1
Status
annotated
Amino acids
781
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006011 The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
73.272
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.64
Structure A0A0H3GYM8
Pocket Pocket 16
P2Rank 0.475
Structure A0A0H3GYM8
Pocket Pocket 1
ColabFold model
FPocket 0.339 · Pocket 5
P2Rank 0.336 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 78 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006011 The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
34 746 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
364 523 Gene3D G3DSA:2.60.120.260 -
1 33 Phobius SIGNAL_PEPTIDE Signal peptide region
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
746 765 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
234 257 PRINTS PR01440 Cellulose synthase subunit B signature
234 257 InterPro IPR003920 Cellulose synthase, subunit B
102 123 PRINTS PR01440 Cellulose synthase subunit B signature
102 123 InterPro IPR003920 Cellulose synthase, subunit B
531 550 PRINTS PR01440 Cellulose synthase subunit B signature
531 550 InterPro IPR003920 Cellulose synthase, subunit B
192 213 PRINTS PR01440 Cellulose synthase subunit B signature
192 213 InterPro IPR003920 Cellulose synthase, subunit B
315 336 PRINTS PR01440 Cellulose synthase subunit B signature
315 336 InterPro IPR003920 Cellulose synthase, subunit B
398 419 PRINTS PR01440 Cellulose synthase subunit B signature
398 419 InterPro IPR003920 Cellulose synthase, subunit B
766 781 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
16 33 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
77 205 Gene3D G3DSA:2.60.120.260 -
73 682 Pfam PF03170 Bacterial cellulose synthase subunit
73 682 InterPro IPR018513 Cellulose synthase BcsB, bacterial
1 777 PANTHER PTHR39083 CYCLIC DI-GMP-BINDING PROTEIN
1 777 InterPro IPR018513 Cellulose synthase BcsB, bacterial
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
747 765 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYM8
AlphaFold — — full sequence — Viewing
ColabFold KP13_00287
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.64

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.47 0.26
2 3.38 0.121
3 2.7 0.08
4 2.02 0.044
5 1.86 0.037