Protein profile

KP13_00288

Endoglucanase

Genome: KpKP13

Gene: bcsZ AHE42199.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZV6
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Amino acids 369
Annotations 5
Features 27
PDB binders 1
Druggability 0.167

Overview

Basic information about this protein and its source genome.

Accession
KP13_00288
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
bcsZ AHE42199.1
Status
annotated
Amino acids
369
Structure source
AlphaFold + ColabFold
EC
3.2.1.4
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0008810 Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. GO:0030245 The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Extracellular
ColabFold pLDDT
93.29

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.167
Structure A0A0H3GZV6
Pocket Pocket 9
P2Rank 0.792
Structure A0A0H3GZV6
Pocket Pocket 1
ColabFold model
FPocket 0.473 · Pocket 3
P2Rank 0.802 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 70 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0008810 Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
  • GO:0030245 The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
2 347 Pfam PF01270 Glycosyl hydrolases family 8
2 347 InterPro IPR002037 Glycoside hydrolase, family 8
1 24 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
16 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
23 361 Gene3D G3DSA:1.50.10.10 -
23 361 InterPro IPR012341 Six-hairpin glycosidase-like superfamily
180 197 PRINTS PR00735 Glycosyl hydrolase family 8 signature
180 197 InterPro IPR002037 Glycoside hydrolase, family 8
115 133 PRINTS PR00735 Glycosyl hydrolase family 8 signature
115 133 InterPro IPR002037 Glycoside hydrolase, family 8
53 66 PRINTS PR00735 Glycosyl hydrolase family 8 signature
53 66 InterPro IPR002037 Glycoside hydrolase, family 8
332 346 PRINTS PR00735 Glycosyl hydrolase family 8 signature
332 346 InterPro IPR002037 Glycoside hydrolase, family 8
216 227 PRINTS PR00735 Glycosyl hydrolase family 8 signature
216 227 InterPro IPR002037 Glycoside hydrolase, family 8
241 250 PRINTS PR00735 Glycosyl hydrolase family 8 signature
241 250 InterPro IPR002037 Glycoside hydrolase, family 8
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
13 352 SUPERFAMILY SSF48208 Six-hairpin glycosidases
13 352 InterPro IPR008928 Six-hairpin glycosidase superfamily
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
23 369 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZV6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00288
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.11 0.712
2 1.31 0.014
3 0.5 0.0

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
MLA
4Q2B
Q88JL2 104.1 Da LogP -0.45 TPSA 74.6 ✓ Ro5 ✓ Clean C(C(=O)O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.