Protein profile

KP13_00292

Peptidase M16 domain-containing protein

Genome: KpKP13

Gene: AHE42202.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZV1
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Amino acids 500
Annotations 3
Features 18
PDB binders 0
Druggability 0.499

Overview

Basic information about this protein and its source genome.

Accession
KP13_00292
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42202.1
Status
annotated
Amino acids
500
Structure source
AlphaFold + ColabFold
GO
GO:0046872 Binding to a metal ion. GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.499
Structure A0A0H3GZV1
Pocket Pocket 25
P2Rank 0.887
Structure A0A0H3GZV1
Pocket Pocket 1
ColabFold model
FPocket 0.091 · Pocket 36
P2Rank 0.905 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 95 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0046872 Binding to a metal ion.
  • GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
25 500 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
9 255 Gene3D G3DSA:3.30.830.10 -
29 239 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase
29 239 InterPro IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
37 476 PANTHER PTHR43690 NARDILYSIN
50 158 Pfam PF00675 Insulinase (Peptidase family M16)
50 158 InterPro IPR011765 Peptidase M16, N-terminal
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
256 471 Gene3D G3DSA:3.30.830.10 -
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
200 377 Pfam PF05193 Peptidase M16 inactive domain
200 377 InterPro IPR007863 Peptidase M16, C-terminal
261 462 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase
261 462 InterPro IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
474 500 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZV1
AlphaFold — — full sequence — Viewing
ColabFold KP13_00292
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
25 0.499
5 0.067
31 0.024
30 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.16 0.887
2 9.04 0.415
3 6.96 0.301
4 6.21 0.257
5 4.55 0.161