Protein profile

KP13_00296

Inner membrane metabolite transport protein

Genome: KpKP13

Gene: AHE42206.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYM1

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Amino acids 440

Annotations 4

Features 52

PDB binders 0

Druggability 0.659

Overview

Basic information about this protein and its source genome.

Accession: KP13_00296
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE42206.1
Status: annotated
Amino acids: 440
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 23.385
Human E-value: 5.68e-06
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 46.469
DEG E-value: 6.79e-111
Localization: CytoplasmicMembrane
ColabFold pLDDT: 91.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.659

Structure A0A0H3GYM1

Pocket Pocket 2

P2Rank 0.892

Structure A0A0H3GYM1

Pocket Pocket 1

ColabFold model

FPocket 0.841 · Pocket 3

P2Rank 0.877 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 163 / 4744 genomes with a hit

Normalized 0.034

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

52 records

Show feature table

Start	End	DB	Term	Name
97	117	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
341	345	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
38	54	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
30	426	NCBIfam	TIGR00883	metabolite/H+ symporter
30	426	InterPro	IPR004736	MFS transporter, metabolite:H symporter
313	320	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
218	248	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
383	405	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
245	439	FunFam	G3DSA:1.20.1250.20:FF:000114	Inner membrane metabolite transporter yhjE
290	312	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
66	85	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
432	440	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
66	88	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
290	312	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
321	340	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
196	218	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
346	370	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
95	117	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
22	417	CDD	cd17369	MFS_ShiA_like
167	189	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
346	368	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
200	217	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
410	432	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
247	269	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
24	226	Pfam	PF00083	Sugar (and other) transporter
24	226	InterPro	IPR005828	Major facilitator, sugar transporter-like
55	65	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
8	439	PANTHER	PTHR43045	SHIKIMATE TRANSPORTER
382	403	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
23	437	ProSiteProfiles	PS50850	Major facilitator superfamily (MFS) profile.
23	437	InterPro	IPR020846	Major facilitator superfamily domain
86	96	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
19	439	SUPERFAMILY	SSF103473	MFS general substrate transporter
19	439	InterPro	IPR036259	MFS transporter superfamily
409	431	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
20	440	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
20	440	InterPro	IPR036259	MFS transporter superfamily
20	237	FunFam	G3DSA:1.20.1250.20:FF:000001	Dicarboxylate MFS transporter
168	188	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
271	289	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
249	270	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
371	381	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	37	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
404	408	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
267	434	Pfam	PF07690	Major Facilitator Superfamily
267	434	InterPro	IPR011701	Major facilitator superfamily
189	199	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24	46	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
308	325	ProSitePatterns	PS00216	Sugar transport proteins signature 1.
308	325	InterPro	IPR005829	Sugar transporter, conserved site
322	341	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
118	167	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GYM1	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_00296	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.659
1				0.535
8				0.45
4				0.231

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	22.81	0.883
2	18.42	0.822
3	5.44	0.259
4	2.21	0.054

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.841
1				0.736
4				0.66
13				0.367

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	21.94	0.875
2	13.39	0.684
3	4.87	0.218