Protein profile

KP13_00319

Nickel transport system permease protein nikC

Genome: KpKP13

Gene: AHE42228.1 nikC Structure source: AlphaFold + ColabFold UniProt A0A0H3GUE7
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Amino acids 277
Annotations 5
Features 32
PDB binders 0
Druggability 0.827

Overview

Basic information about this protein and its source genome.

Accession
KP13_00319
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42228.1 nikC
Status
annotated
Amino acids
277
Structure source
AlphaFold + ColabFold
GO
GO:0015099 Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.613
DEG E-value
1.64e-63
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.827
Structure A0A0H3GUE7
Pocket Pocket 2
P2Rank 0.322
Structure A0A0H3GUE7
Pocket Pocket 1
ColabFold model
FPocket 0.446 · Pocket 12
P2Rank 0.298 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 37 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0015099 Enables the transfer of nickel (Ni) cations from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
197 202 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
33 74 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
205 227 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 32 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
75 100 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
177 196 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
242 260 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
101 120 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
179 198 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
104 263 CDD cd06261 TM_PBP2
104 263 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
61 268 Gene3D G3DSA:1.10.3720.10 -
61 268 InterPro IPR035906 MetI-like superfamily
89 271 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
89 271 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
149 176 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 253 SUPERFAMILY SSF161098 MetI-like
66 253 InterPro IPR035906 MetI-like superfamily
121 143 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
261 277 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 268 NCBIfam TIGR02790 nickel ABC transporter permease subunit NikC
12 268 InterPro IPR014157 Nickel ABC transporter, permease subunit NikC
223 241 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
78 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
242 260 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 260 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
71 260 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
203 222 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
121 148 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 270 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUE7
AlphaFold — — full sequence — Viewing
ColabFold KP13_00319
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.827
15 0.704
8 0.207
6 0.206

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.25 0.313
2 2.27 0.057
3 2.07 0.046
4 1.2 0.011
5 1.09 0.007