Protein profile

KP13_31568

Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE

Genome: KpKP13

Gene: AHE42237.1 arnE Structure source: AlphaFold + ColabFold UniProt A0A0H3GUE3
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Amino acids 112
Annotations 6
Features 25
PDB binders 0
Druggability 0.74

Overview

Basic information about this protein and its source genome.

Accession
KP13_31568
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42237.1 arnE
Status
annotated
Amino acids
112
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:1901505 Enables the transfer of carbohydrate derivative from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009245 The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
48.0
DEG E-value
2.56e-19
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.74
Structure A0A0H3GUE3
Pocket Pocket 1
P2Rank 0.157
Structure A0A0H3GUE3
Pocket Pocket 1
ColabFold model
FPocket 0.564 · Pocket 1
P2Rank 0.148 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
  • GO:1901505 Enables the transfer of carbohydrate derivative from one side of a membrane to the other.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0009245 The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
3 111 FunFam G3DSA:1.10.3730.20:FF:000002 Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
37 59 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
60 65 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
93 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
111 112 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 109 PANTHER PTHR30561 SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE
1 109 InterPro IPR000390 Small drug/metabolite transporter protein family
14 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
22 36 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
92 110 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
2 108 Pfam PF00892 EamA-like transporter family
2 108 InterPro IPR000620 EamA domain
1 111 Gene3D G3DSA:1.10.3730.20 -
1 17 SignalP_EUK SignalP-TM SignalP-TM
37 59 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
6 109 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
64 86 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
87 91 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 112 Hamap MF_01869 Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE [arnE].
2 112 InterPro IPR022883 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase, subunit ArnE
66 86 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUE3
AlphaFold — — full sequence — Viewing
ColabFold KP13_31568
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.74

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.35 0.119
2 3.22 0.111
3 1.36 0.016