Protein profile

KP13_00330

Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF

Genome: KpKP13

Gene: AHE42238.1 arnF Structure source: AlphaFold + ColabFold UniProt A0A0H3H482
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Amino acids 126
Annotations 4
Features 22
PDB binders 0
Druggability 0.665

Overview

Basic information about this protein and its source genome.

Accession
KP13_00330
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42238.1 arnF
Status
annotated
Amino acids
126
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:1901505 Enables the transfer of carbohydrate derivative from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
44.882
DEG E-value
1.98e-22
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.665
Structure A0A0H3H482
Pocket Pocket 4
P2Rank 0.057
Structure A0A0H3H482
Pocket Pocket 1
ColabFold model
FPocket 0.418 · Pocket 5
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 51 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
  • GO:1901505 Enables the transfer of carbohydrate derivative from one side of a membrane to the other.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
1 15 Phobius SIGNAL_PEPTIDE Signal peptide region
124 126 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
76 97 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
3 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
96 100 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
101 123 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
68 75 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 123 PANTHER PTHR30561 SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE
1 123 InterPro IPR000390 Small drug/metabolite transporter protein family
2 122 Gene3D G3DSA:1.10.3730.20 -
47 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 125 Hamap MF_00538 Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF [arnF].
1 125 InterPro IPR022832 Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF
11 15 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
16 47 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
76 95 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
48 67 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
42 122 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
101 123 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 15 SignalP_EUK SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H482
AlphaFold — — full sequence — Viewing
ColabFold KP13_00330
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.665
6 0.524
1 0.262
9 0.226

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.94 0.04