Protein profile

KP13_00334

putative integral membrane protein

Genome: KpKP13

Gene: AHE42242.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H477
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Amino acids 221
Annotations 1
Features 27
PDB binders 0
Druggability 0.987

Overview

Basic information about this protein and its source genome.

Accession
KP13_00334
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42242.1
Status
annotated
Amino acids
221
Structure source
AlphaFold + ColabFold
GO
GO:1990397 OBSOLETE. Any process which produces queuosine from derivatives of it, without de novo synthesis.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.33
DEG E-value
2.84e-140
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.987
Structure A0A0H3H477
Pocket Pocket 13
P2Rank 0.947
Structure A0A0H3H477
Pocket Pocket 1
ColabFold model
FPocket 0.989 · Pocket 13
P2Rank 0.946 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 171 / 4744 genomes with a hit
Normalized 0.036

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:1990397 OBSOLETE. Any process which produces queuosine from derivatives of it, without de novo synthesis.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
142 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 210 PANTHER PTHR34300 QUEUOSINE PRECURSOR TRANSPORTER-RELATED
4 210 InterPro IPR003744 Queuosine precursor transporter
45 64 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 92 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 36 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
183 206 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
120 139 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
60 70 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
164 182 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
207 221 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
98 119 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
93 97 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
43 198 Pfam PF02592 Putative vitamin uptake transporter
43 198 InterPro IPR003744 Queuosine precursor transporter
140 163 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
184 206 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 211 Hamap MF_02088 Probable queuosine precursor transporter.
14 211 InterPro IPR003744 Queuosine precursor transporter
71 93 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 31 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 205 NCBIfam TIGR00697 queuosine precursor transporter
12 205 InterPro IPR003744 Queuosine precursor transporter
37 59 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
108 130 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H477
AlphaFold — — full sequence — Viewing
ColabFold KP13_00334
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.987
3 0.813

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.41 0.931