Protein profile

KP13_00335

Sulfurtransferase tusA

Genome: KpKP13

Gene: AHE42243.1 tusA Structure source: AlphaFold + ColabFold UniProt A0A0H3GWZ6
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Amino acids 81
Annotations 3
Features 13
PDB binders 0
Druggability 0.25

Overview

Basic information about this protein and its source genome.

Accession
KP13_00335
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42243.1 tusA
Status
annotated
Amino acids
81
Structure source
AlphaFold + ColabFold
GO
GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
86.42
DEG E-value
5.65e-50
Localization
Cytoplasmic
ColabFold pLDDT
95.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.25
Structure A0A0H3GWZ6
Pocket Pocket 3
P2Rank
Structure A0A0H3GWZ6
Pocket No pockets
ColabFold model
FPocket 0.372 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 151 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule.
  • GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 80 Gene3D G3DSA:3.30.110.40 -
1 80 InterPro IPR036868 TusA-like domain superfamily
12 36 ProSitePatterns PS01148 Uncharacterized protein family UPF0033 signature.
12 36 InterPro IPR001455 TusA-like domain
3 81 Hamap MF_00413 Sulfur carrier protein TusA [tusA].
3 81 InterPro IPR022931 Sulfur carrier protein TusA
4 80 PANTHER PTHR33279 SULFUR CARRIER PROTEIN YEDF-RELATED
4 79 SUPERFAMILY SSF64307 SirA-like
4 79 InterPro IPR036868 TusA-like domain superfamily
10 79 Pfam PF01206 Sulfurtransferase TusA
10 79 InterPro IPR001455 TusA-like domain
11 79 CDD cd03423 SirA
11 79 InterPro IPR022931 Sulfur carrier protein TusA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWZ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00335
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.25