Protein profile

KP13_31766

cell division protein FtsY

Genome: KpKP13

Gene: ftsY AHE42249.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYJ7

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Amino acids 507

Annotations 9

Features 35

PDB binders 9

Druggability 0.076

Overview

Basic information about this protein and its source genome.

Accession: KP13_31766
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: ftsY AHE42249.1
Status: annotated
Amino acids: 507
Structure source: AlphaFold + ColabFold

3.6.5.4

GO:0006614 The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. GO:0005525 Binding to GTP, guanosine triphosphate. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003924 Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 34.975
Human E-value: 1.48e-31
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 77.351
DEG E-value: 0.0
Localization: Cytoplasmic
ColabFold pLDDT: 72.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.076

Structure A0A0H3GYJ7

Pocket Pocket 32

P2Rank 0.129

Structure A0A0H3GYJ7

Pocket Pocket 1

ColabFold model

FPocket 0.284 · Pocket 2

P2Rank 0.173 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 60 / 4744 genomes with a hit

Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

3.6.5.4

Gene Ontology (GO)

GO:0006614 The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
GO:0005525 Binding to GTP, guanosine triphosphate.
GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0003924 Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
GO:0005047 Binding to a signal recognition particle.
GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records

Show feature table

Start	End	DB	Term	Name
193	293	Gene3D	G3DSA:1.20.120.140	-
193	293	InterPro	IPR042101	Signal recognition particle SRP54, N-terminal domain superfamily
232	503	NCBIfam	TIGR00064	signal recognition particle-docking protein FtsY
232	503	InterPro	IPR004390	Signal-recognition particle receptor FtsY
8	16	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	121	MobiDBLite	mobidb-lite	consensus disorder prediction
304	502	CDD	cd17874	FtsY
220	285	Pfam	PF02881	SRP54-type protein, helical bundle domain
220	285	InterPro	IPR013822	Signal recognition particle SRP54, helical bundle
1	7	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
232	504	Hamap	MF_00920	Signal recognition particle receptor FtsY [ftsY].
232	504	InterPro	IPR004390	Signal-recognition particle receptor FtsY
302	493	SMART	SM00382	AAA_5
302	493	InterPro	IPR003593	AAA+ ATPase domain
22	507	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
303	503	Pfam	PF00448	SRP54-type protein, GTPase domain
303	503	InterPro	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain
17	21	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
303	504	SMART	SM00962	SRP54_3
303	504	InterPro	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain
296	504	FunFam	G3DSA:3.40.50.300:FF:000053	Signal recognition particle receptor FtsY
295	507	Gene3D	G3DSA:3.40.50.300	-
295	507	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
1	21	Phobius	SIGNAL_PEPTIDE	Signal peptide region
199	293	FunFam	G3DSA:1.20.120.140:FF:000002	Signal recognition particle receptor FtsY
204	283	SUPERFAMILY	SSF47364	Domain of the SRP/SRP receptor G-proteins
204	283	InterPro	IPR036225	SRP/SRP receptor, N-terminal
209	289	SMART	SM00963	SRP54_N_2
209	289	InterPro	IPR013822	Signal recognition particle SRP54, helical bundle
477	490	ProSitePatterns	PS00300	SRP54-type proteins GTP-binding domain signature.
477	490	InterPro	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain
6	503	PANTHER	PTHR43134	SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA
296	503	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
296	503	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
68	84	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GYJ7	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_31766	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Sticks	Spheres	Surfaces	Score	Probability	Labels	Zoom	Positions
1				2.96	0.096

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.284

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Sticks	Spheres	Surfaces	Score	Probability	Labels	Zoom	Positions
1				1.64	0.027

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

59 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
0O2	7O9H	P10121	683.1 Da LogP -2.10 TPSA 392.2	3 viol.	✓ Clean	`c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…`
4ME	6CVD	P10121	175.2 Da LogP 1.95 TPSA 42.1	✓ Ro5	✓ Clean	`COC(=O)c1cccc2c1cc[nH]2`
ALF	4C7O	P10121	103.0 Da LogP 1.30 TPSA 0.0	✓ Ro5	✓ Clean	`F[Al-](F)(F)F`
F9Y	6CS8	P10121	142.2 Da LogP 2.04 TPSA 39.6	✓ Ro5	✓ Clean	`c1cc(cc2c1cc[nH]2)C#N`
GCP	5L3R	O80842	521.2 Da LogP -2.22 TPSA 289.9	3 viol.	✓ Clean	`c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…`
GNP	5NIY	P10121	522.2 Da LogP -2.76 TPSA 301.9	3 viol.	✓ Clean	`c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…`
GXY	6DLX	P10121	232.1 Da LogP 2.05 TPSA 44.5	✓ Ro5	✓ Clean	`COc1cc(c(cc1Br)OC)N`
MLI	2OG2	O80842	102.0 Da LogP -3.12 TPSA 80.3	✓ Ro5	✓ Clean	`C(C(=O)[O-])C(=O)[O-]`
NH4	6CVD	P10121	18.0 Da LogP 0.38 TPSA 36.5	✓ Ro5	✓ Clean	`[NH4+]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC9372393	1.000	232.1 Da LogP 2.05 TPSA 44.5	✓ Ro5	✓ Clean	`COc1cc(Br)c(OC)cc1N`
ZINC34541308	0.850	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC104869865	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(O…`
ZINC12504289	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC35000839	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC45284491	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC80639694	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC8215481	0.836	443.2 Da LogP -2.45 TPSA 252.6	2 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@@](=O)(O)OP(=O)(…`
ZINC36181635	0.826	232.1 Da LogP 2.05 TPSA 44.5	✓ Ro5	✓ Clean	`COc1cc(OC)c(Br)cc1N`
ZINC39590917	0.783	217.1 Da LogP 1.62 TPSA 61.3	✓ Ro5	✓ Clean	`COc1cc(N)c(N)cc1Br`
ZINC494861	0.783	280.9 Da LogP 2.80 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(Br)cc1N`
ZINC12501413	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)…`
ZINC12958448	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@H](O)[…`
ZINC1532555	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](COP(=O)(O)O)[C@H](O)[…`
ZINC16546189	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@H](O)[…`
ZINC2159505	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)…`
ZINC3073318	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](COP(=O)(O)O)[C@@H](O)…`
ZINC3869963	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](COP(=O)(O)O)[C@@H](O)…`
ZINC3869965	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@@H](COP(=O)(O)O)[C@@H](O…`
ZINC9334496	0.770	363.2 Da LogP -2.57 TPSA 206.0	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@H]2O[C@@H](COP(=O)(O)O)[C@H](O)[…`
ZINC72204055	0.750	280.9 Da LogP 2.80 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(N)cc1Br`
ZINC8737772	0.750	280.9 Da LogP 2.80 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(Br)cc1Br`
ZINC16678131	0.720	216.1 Da LogP 2.35 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(C)cc1Br`
ZINC4707252	0.720	402.1 Da LogP 4.06 TPSA 70.5	✓ Ro5	✓ Clean	`COc1cc(-c2cc(OC)c(N)cc2Br)c(Br)cc1N`
ZINC57059	0.714	296.0 Da LogP 3.23 TPSA 18.5	✓ Ro5	✓ Clean	`COc1cc(Br)c(OC)cc1Br`
ZINC1685331	0.708	232.1 Da LogP 2.05 TPSA 44.5	✓ Ro5	✓ Clean	`COc1cc(N)c(Br)cc1OC`
ZINC1532902	0.700	206.2 Da LogP -0.86 TPSA 132.1	✓ Ro5	✓ Clean	`O=C(O)CC[C@@](O)(CC(=O)O)C(=O)O`
ZINC2018106	0.700	206.2 Da LogP -0.86 TPSA 132.1	✓ Ro5	✓ Clean	`O=C(O)CC[C@](O)(CC(=O)O)C(=O)O`
ZINC40571453	0.692	216.1 Da LogP 2.35 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(C)cc1N`
ZINC33358958	0.686	203.2 Da LogP 1.31 TPSA 59.2	✓ Ro5	✓ Clean	`COC(=O)c1cccc2c(=O)[nH]ccc12`
ZINC71774763	0.671	432.3 Da LogP -2.23 TPSA 198.3	1 viol.	✓ Clean	`Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@](=O)(O)N3CCOCC3…`
ZINC14982814	0.667	233.2 Da LogP 1.74 TPSA 68.4	✓ Ro5	✓ Clean	`COC(=O)c1cc(C(=O)OC)c2cc[nH]c2c1`
ZINC149859436	0.667	327.9 Da LogP 2.64 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(I)cc1Br`
ZINC15444513	0.667	236.5 Da LogP 2.69 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(Cl)cc1N`
ZINC20283497	0.667	304.3 Da LogP 2.55 TPSA 89.0	✓ Ro5	✓ Clean	`COc1cc(-c2cc(OC)c(N)cc2OC)c(OC)cc1N`
ZINC34363585	0.667	236.5 Da LogP 2.69 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(Cl)cc1Br`
ZINC39619094	0.667	220.0 Da LogP 2.18 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(N)c(F)cc1Br`
ZINC77032296	0.667	220.0 Da LogP 2.18 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(F)cc1N`
ZINC97447173	0.667	218.0 Da LogP 1.75 TPSA 55.5	✓ Ro5	✓ Clean	`COc1cc(N)c(O)cc1Br`
ZINC97447174	0.667	218.0 Da LogP 1.75 TPSA 55.5	✓ Ro5	✓ Clean	`COc1cc(Br)c(O)cc1N`
ZINC83428754	0.654	216.1 Da LogP 2.35 TPSA 35.2	✓ Ro5	✓ Clean	`COc1cc(C)c(N)cc1Br`
ZINC163122	0.652	247.1 Da LogP 2.47 TPSA 27.7	✓ Ro5	✓ Clean	`COc1cc(OC)c(OC)cc1Br`
ZINC1721293	0.652	344.8 Da LogP 3.98 TPSA 9.2	✓ Ro5	✓ Clean	`COc1cc(Br)c(Br)cc1Br`
ZINC3593496	0.652	206.2 Da LogP -1.16 TPSA 121.1	✓ Ro5	✓ Clean	`COC(=O)C[C@@](O)(CC(=O)O)C(=O)O`
ZINC3593497	0.652	206.2 Da LogP -1.16 TPSA 121.1	✓ Ro5	✓ Clean	`COC(=O)C[C@](O)(CC(=O)O)C(=O)O`
ZINC4743771	0.652	361.3 Da LogP -2.70 TPSA 182.6	1 viol.	✓ Clean	`CS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc…`
ZINC4743772	0.652	361.3 Da LogP -2.70 TPSA 182.6	1 viol.	✓ Clean	`CS(=O)(=O)OC[C@@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)n…`
ZINC4743774	0.652	361.3 Da LogP -2.70 TPSA 182.6	1 viol.	✓ Clean	`CS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc…`
ZINC4743775	0.652	361.3 Da LogP -2.70 TPSA 182.6	1 viol.	✓ Clean	`CS(=O)(=O)OC[C@@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)n…`
ZINC238405705	0.649	203.2 Da LogP 1.31 TPSA 59.2	✓ Ro5	✓ Clean	`COC(=O)c1cccc2[nH]ccc(=O)c12`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.