Protein profile

KP13_00649

sn-glycerol-3-phosphate transport system permease protein ugpE

Genome: KpKP13

Gene: ugpE AHE42269.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYI6
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Amino acids 281
Annotations 3
Features 33
PDB binders 0
Druggability 0.638

Overview

Basic information about this protein and its source genome.

Accession
KP13_00649
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ugpE AHE42269.1
Status
annotated
Amino acids
281
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.638
Structure A0A0H3GYI6
Pocket Pocket 1
P2Rank 0.274
Structure A0A0H3GYI6
Pocket Pocket 1
ColabFold model
FPocket 0.535 · Pocket 13
P2Rank 0.229 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 145 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
1 14 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
77 268 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
77 268 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
2 274 Gene3D G3DSA:1.10.3720.10 -
2 274 InterPro IPR035906 MetI-like superfamily
250 272 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
245 267 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 279 PANTHER PTHR43744 ABC TRANSPORTER PERMEASE PROTEIN MG189-RELATED-RELATED
82 104 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
37 80 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
81 105 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
239 249 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
112 133 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
216 238 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
106 111 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
134 144 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
187 210 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
167 186 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
145 162 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
92 276 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
92 276 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
111 130 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
145 166 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
273 281 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
200 222 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
211 215 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 274 FunFam G3DSA:1.10.3720.10:FF:000042 sn-glycerol-3-phosphate transport system permease protein UgpE
4 277 SUPERFAMILY SSF161098 MetI-like
4 277 InterPro IPR035906 MetI-like superfamily
77 259 CDD cd06261 TM_PBP2
77 259 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYI6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00649
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.638
3 0.097
7 0.067
2 0.03

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.48 0.274
2 3.09 0.083
3 1.82 0.029
4 1.82 0.029
5 1.25 0.011