Protein profile

KP13_09671

sn-glycerol-3-phosphate import ATP-binding protein ugpC

Genome: KpKP13

Gene: ANJ86569.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZL9
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Amino acids 367
Annotations 7
Features 26
PDB binders 5
Druggability 0.352

Overview

Basic information about this protein and its source genome.

Accession
KP13_09671
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86569.1
Status
annotated
Amino acids
367
Structure source
AlphaFold + ColabFold
GO
GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140359 Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0055052 A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. GO:0015794 The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
51.282
Human E-value
6.51e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
48.794
DEG E-value
1.77e-120
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.76

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.352
Structure A0A0H3GZL9
Pocket Pocket 2
P2Rank 0.216
Structure A0A0H3GZL9
Pocket Pocket 1
ColabFold model
FPocket 0.599 · Pocket 1
P2Rank 0.315 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 318 / 4744 genomes with a hit
Normalized 0.067

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0140359 Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
  • GO:0055052 A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
  • GO:0015794 The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol.
  • GO:0001407 The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
306 350 FunFam G3DSA:2.40.50.140:FF:000142 sn-glycerol-3-phosphate import ATP-binding protein UgpC
251 297 FunFam G3DSA:2.40.50.100:FF:000032 sn-glycerol-3-phosphate import ATP-binding protein UgpC
251 364 Gene3D G3DSA:2.40.50.100 -
247 296 Pfam PF17912 MalK OB fold domain
247 296 InterPro IPR040582 MalK-like, OB fold domain
12 366 PANTHER PTHR43875 MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MSMX
12 366 InterPro IPR047641 ABC transporter, ATP-binding protein MalK/UgpC-like
40 337 SMART SM00382 AAA_5
40 337 InterPro IPR003593 AAA+ ATPase domain
5 250 Gene3D G3DSA:3.40.50.300 -
5 250 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
15 254 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
15 254 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
306 350 Gene3D G3DSA:2.40.50.140 -
306 350 InterPro IPR012340 Nucleic acid-binding, OB-fold
15 228 CDD cd03301 ABC_MalK_N
15 228 InterPro IPR015855 ABC transporter, maltose/maltodextrin import, MalK-like
146 160 ProSitePatterns PS00211 ABC transporters family signature.
146 160 InterPro IPR017871 ABC transporter-like, conserved site
12 250 FunFam G3DSA:3.40.50.300:FF:000042 Maltose/maltodextrin ABC transporter, ATP-binding protein
32 173 Pfam PF00005 ABC transporter
32 173 InterPro IPR003439 ABC transporter-like, ATP-binding domain
248 366 SUPERFAMILY SSF50331 MOP-like
248 366 InterPro IPR008995 Molybdate/tungstate binding, C-terminal
15 246 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile.
15 246 InterPro IPR003439 ABC transporter-like, ATP-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZL9
AlphaFold — — full sequence — Viewing
ColabFold KP13_09671
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.352
8 0.23

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.97 0.157
2 1.97 0.042
3 1.92 0.039

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
2BA
7AHE
Q9KIF7 658.4 Da LogP -1.63 TPSA 309.7 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)C…
ANP
6Z67
Q8DQH4 506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
BET
7AHH
Q9KIF7 118.2 Da LogP -0.22 TPSA 37.3 ✓ Ro5 ✓ Clean C[N+](C)(C)CC(=O)O
NH4
1G29
Q9YGA6 18.0 Da LogP 0.38 TPSA 36.5 ✓ Ro5 ✓ Clean [NH4+]
POP
2D62
O57933 176.0 Da LogP -2.08 TPSA 129.9 ✓ Ro5 ✓ Clean O[P@@](=O)([O-])O[P@@](=O)(O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.