Protein profile

KP13_00669

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE42288.1 Structure source: AlphaFold + ColabFold UniProt A0A231WWU8
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Amino acids 99
Annotations 1
Features 12
PDB binders 0
Druggability 0.651

Overview

Basic information about this protein and its source genome.

Accession
KP13_00669
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42288.1
Status
annotated
Amino acids
99
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.651
Structure A0A231WWU8
Pocket Pocket 1
P2Rank
Structure A0A231WWU8
Pocket No pockets
ColabFold model
FPocket 0.251 · Pocket 2
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
31 86 SMART SM00530 mbf_short4
31 86 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
9 87 Pfam PF13744 Helix-turn-helix domain
9 87 InterPro IPR039554 HigA2-like, helix-turn-helix domain
32 86 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
32 86 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
30 90 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
30 90 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
31 84 CDD cd00093 HTH_XRE
31 84 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
8 96 Gene3D G3DSA:1.10.260.40 -
8 96 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A231WWU8
AlphaFold — — full sequence — Viewing
ColabFold KP13_00669
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.651