Protein profile

KP13_00678

High-affinity gluconate transporter

Genome: KpKP13

Gene: AHE42298.1 gntT Structure source: AlphaFold + ColabFold UniProt A0A0H3GUB1
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Amino acids 438
Annotations 4
Features 43
PDB binders 0
Druggability 0.749

Overview

Basic information about this protein and its source genome.

Accession
KP13_00678
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42298.1 gntT
Status
annotated
Amino acids
438
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015128 Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429 The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.749
Structure A0A0H3GUB1
Pocket Pocket 3
P2Rank 0.84
Structure A0A0H3GUB1
Pocket Pocket 1
ColabFold model
FPocket 0.82 · Pocket 13
P2Rank 0.847 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 159 / 4744 genomes with a hit
Normalized 0.034

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015128 Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose.
  • GO:0035429 The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

43 records
Show feature table
Start End DB Term Name
367 377 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
337 366 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
17 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
4 18 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
58 76 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
53 75 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
415 437 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
317 336 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
258 280 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 438 PIRSF PIRSF002746 Gluconate_transporter
1 438 InterPro IPR003474 Gluconate transporter
402 412 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
155 174 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
132 154 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 57 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
378 401 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
247 257 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
175 197 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
298 316 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
224 246 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
378 400 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
77 96 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
100 122 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
413 437 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
198 223 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 438 PANTHER PTHR30354 GNT FAMILY GLUCONATE TRANSPORTER
2 438 InterPro IPR003474 Gluconate transporter
258 278 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
293 312 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
344 366 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
175 197 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
279 297 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
97 130 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
136 154 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 437 Pfam PF02447 GntP family permease
1 437 InterPro IPR003474 Gluconate transporter
3 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
131 135 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 438 NCBIfam TIGR00791 gluconate:H+ symporter
438 438 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUB1
AlphaFold — — full sequence — Viewing
ColabFold KP13_00678
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.749
19 0.544
12 0.465
1 0.4

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.09 0.674
2 4.04 0.162
3 2.04 0.045