Protein profile

KP13_00679

Fe/S biogenesis protein nfuA

Genome: KpKP13

Gene: nfuA AHE42299.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H436
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Amino acids 191
Annotations 5
Features 19
PDB binders 0
Druggability 0.387

Overview

Basic information about this protein and its source genome.

Accession
KP13_00679
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
nfuA AHE42299.1
Status
annotated
Amino acids
191
Structure source
AlphaFold + ColabFold
GO
GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051604 Any process leading to the attainment of the full functional capacity of a protein. GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005506 Binding to an iron (Fe) ion. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
49.032
DEG E-value
4.7599999999999995e-48
Localization
Cytoplasmic
ColabFold pLDDT
84.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.387
Structure A0A0H3H436
Pocket Pocket 1
P2Rank
Structure A0A0H3H436
Pocket No pockets
ColabFold model
FPocket 0.482 · Pocket 1
P2Rank 0.236 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 158 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0051604 Any process leading to the attainment of the full functional capacity of a protein.
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
111 177 Pfam PF01106 NifU-like domain
111 177 InterPro IPR001075 NIF system FeS cluster assembly, NifU, C-terminal
101 188 Gene3D G3DSA:3.30.300.130 -
101 188 InterPro IPR034904 Fe-S cluster assembly domain superfamily
2 191 NCBIfam TIGR03341 Fe-S biogenesis protein NfuA
2 191 InterPro IPR017726 Fe/S biogenesis protein NfuA
1 97 SUPERFAMILY SSF89360 HesB-like domain
1 97 InterPro IPR035903 HesB-like domain superfamily
1 98 FunFam G3DSA:2.60.300.12:FF:000004 Fe/S biogenesis protein NfuA
1 191 Hamap MF_01637 Fe/S biogenesis protein NfuA [nfuA].
1 191 InterPro IPR017726 Fe/S biogenesis protein NfuA
1 98 Gene3D G3DSA:2.60.300.12 -
1 98 InterPro IPR035903 HesB-like domain superfamily
101 188 FunFam G3DSA:3.30.300.130:FF:000002 Fe/S biogenesis protein NfuA
2 98 Pfam PF01521 Iron-sulphur cluster biosynthesis
2 98 InterPro IPR000361 FeS cluster biogenesis
95 184 SUPERFAMILY SSF117916 Fe-S cluster assembly (FSCA) domain-like
95 184 InterPro IPR034904 Fe-S cluster assembly domain superfamily
86 183 PANTHER PTHR11178 IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H436
AlphaFold — — full sequence — Viewing
ColabFold KP13_00679
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.387