Protein profile

KP13_31748

Ferrous iron transport protein A

Genome: KpKP13

Gene: AHE42305.1 feoA Structure source: Experimental + ColabFold UniProt A6TF31
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Amino acids 75
Annotations 1
Features 9
PDB binders 0
Druggability 0.318

Overview

Basic information about this protein and its source genome.

Accession
KP13_31748
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42305.1 feoA
Status
annotated
Amino acids
75
Structure source
Experimental + ColabFold
GO
GO:0046914 Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.741
DEG E-value
5.42e-10
Localization
Unknown
ColabFold pLDDT
86.86

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.318
Structure 6E55
Pocket Pocket 4
P2Rank
Structure 6E55
Pocket No pockets
ColabFold model
FPocket 0.475 · Pocket 3
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 110 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0046914 Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
2 72 PANTHER PTHR42954 FE(2+) TRANSPORT PROTEIN A
10 71 Pfam PF04023 FeoA domain
10 71 InterPro IPR007167 Ferrous iron transporter FeoA domain
1 72 SMART SM00899 FeoA_2
1 72 InterPro IPR007167 Ferrous iron transporter FeoA domain
7 75 Gene3D G3DSA:2.30.30.90 -
7 75 InterPro IPR038157 Ferrous iron transporter, core domain
2 72 SUPERFAMILY SSF50037 C-terminal domain of transcriptional repressors
2 72 InterPro IPR008988 Transcriptional repressor, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6E55
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_31748
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
40 0.329

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.0 0.634
2 7.16 0.372
3 1.74 0.031
4 1.36 0.016
5 1.27 0.013