Protein profile

KP13_00686

hypothetical protein

Genome: KpKP13

Gene: AHE42306.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYF8
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Amino acids 776
Annotations 6
Features 41
PDB binders 1
Druggability 0.251

Overview

Basic information about this protein and its source genome.

Accession
KP13_00686
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42306.1
Status
annotated
Amino acids
776
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0006139 Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
37.931
Human E-value
8.37e-07
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
71.762
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.251
Structure A0A0H3GYF8
Pocket Pocket 36
P2Rank 0.803
Structure A0A0H3GYF8
Pocket Pocket 1
ColabFold model
FPocket 0.588 · Pocket 6
P2Rank 0.927 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 294 / 4744 genomes with a hit
Normalized 0.062

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0003676 Binding to a nucleic acid.
  • GO:0006139 Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
111 328 FunFam G3DSA:1.10.3500.10:FF:000002 RNA-binding transcriptional accessory protein
561 630 Pfam PF17674 HHH domain
561 630 InterPro IPR041692 HHH domain 9
327 424 SMART SM00732 rnase_8s
327 424 InterPro IPR006641 YqgF/RNase H-like domain
111 498 Gene3D G3DSA:1.10.3500.10 -
111 498 InterPro IPR023323 Tex-like domain superfamily
649 720 SMART SM00316 S1_6
649 720 InterPro IPR022967 RNA-binding domain, S1
720 776 MobiDBLite mobidb-lite consensus disorder prediction
491 555 Pfam PF12836 Helix-hairpin-helix motif
10 193 Pfam PF09371 Tex-like protein N-terminal domain
10 193 InterPro IPR018974 Tex-like protein, N-terminal
631 724 Gene3D G3DSA:2.40.50.140 -
631 724 InterPro IPR012340 Nucleic acid-binding, OB-fold
3 110 Gene3D G3DSA:1.10.10.650 -
3 110 InterPro IPR023319 Tex-like protein, HTH domain superfamily
470 558 SUPERFAMILY SSF47781 RuvA domain 2-like
470 558 InterPro IPR010994 RuvA domain 2-like
651 718 CDD cd05685 S1_Tex
651 718 InterPro IPR044146 Tex, S1 domain
651 720 ProSiteProfiles PS50126 S1 domain profile.
651 720 InterPro IPR003029 S1 domain
326 451 Gene3D G3DSA:3.30.420.140 -
326 451 InterPro IPR037027 YqgF/RNase H-like domain superfamily
2 322 SUPERFAMILY SSF158832 Tex N-terminal region-like
323 469 SUPERFAMILY SSF53098 Ribonuclease H-like
323 469 InterPro IPR012337 Ribonuclease H-like superfamily
638 722 SUPERFAMILY SSF50249 Nucleic acid-binding proteins
638 722 InterPro IPR012340 Nucleic acid-binding, OB-fold
499 630 Gene3D G3DSA:1.10.150.310 -
39 744 PANTHER PTHR10724 30S RIBOSOMAL PROTEIN S1
2 110 FunFam G3DSA:1.10.10.650:FF:000001 S1 RNA-binding domain 1
328 451 Pfam PF16921 Tex protein YqgF-like domain
328 451 InterPro IPR032639 Tex protein, YqgF-like domain
651 720 Pfam PF00575 S1 RNA binding domain
560 632 SUPERFAMILY SSF47781 RuvA domain 2-like
560 632 InterPro IPR010994 RuvA domain 2-like
326 451 FunFam G3DSA:3.30.420.140:FF:000001 RNA-binding transcriptional accessory protein
499 630 FunFam G3DSA:1.10.150.310:FF:000001 RNA-binding transcriptional accessory protein
634 724 FunFam G3DSA:2.40.50.140:FF:000051 RNA-binding transcriptional accessory protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYF8
AlphaFold — — full sequence — Viewing
ColabFold KP13_00686
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
36 0.251

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.12 0.544
2 5.07 0.231
3 2.61 0.075
4 2.14 0.05
5 1.82 0.035

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

39 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
VGL
4NNI
P9WH43 124.1 Da LogP 0.17 TPSA 63.1 ✓ Ro5 ✓ Clean c1cnc(cn1)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.