Protein profile

KP13_00693

Heat shock protein 15

Genome: KpKP13

Gene: AHE42313.1 hslR Structure source: AlphaFold + ColabFold UniProt A0A0H3GU81
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Amino acids 133
Annotations 5
Features 13
PDB binders 0
Druggability 0.32

Overview

Basic information about this protein and its source genome.

Accession
KP13_00693
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42313.1 hslR
Status
annotated
Amino acids
133
Structure source
AlphaFold + ColabFold
GO
GO:0034605 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. GO:0043023 Binding to a large ribosomal subunit. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0003727 Binding to single-stranded RNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.6

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.32
Structure A0A0H3GU81
Pocket Pocket 10
P2Rank
Structure A0A0H3GU81
Pocket No pockets
ColabFold model
FPocket 0.383 · Pocket 6
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 178 / 4744 genomes with a hit
Normalized 0.038

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0034605 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
  • GO:0043023 Binding to a large ribosomal subunit.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0003727 Binding to single-stranded RNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 108 Gene3D G3DSA:3.10.290.10 -
1 108 InterPro IPR036986 RNA-binding S4 domain superfamily
103 133 MobiDBLite mobidb-lite consensus disorder prediction
8 103 SUPERFAMILY SSF55174 Alpha-L RNA-binding motif
9 52 Pfam PF01479 S4 domain
9 52 InterPro IPR002942 RNA-binding S4 domain
108 133 MobiDBLite mobidb-lite consensus disorder prediction
9 71 ProSiteProfiles PS50889 S4 RNA-binding domain profile.
9 58 CDD cd00165 S4
9 70 SMART SM00363 s4_6
9 70 InterPro IPR002942 RNA-binding S4 domain
6 133 PIRSF PIRSF016821 HSP15
6 133 InterPro IPR025708 Heat shock protein 15

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU81
AlphaFold — — full sequence — Viewing
ColabFold KP13_00693
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.32
11 0.265