Protein profile

KP13_00705

Protein damX

Genome: KpKP13

Gene: damX AHE42323.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H403
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Amino acids 424
Annotations 3
Features 21
PDB binders 0
Druggability 0.103

Overview

Basic information about this protein and its source genome.

Accession
KP13_00705
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
damX AHE42323.1
Status
annotated
Amino acids
424
Structure source
AlphaFold + ColabFold
GO
GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0032506 A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
61.937
DEG E-value
2.4e-134
Localization
OuterMembrane
ColabFold pLDDT
57.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.103
Structure A0A0H3H403
Pocket Pocket 15
P2Rank 0.019
Structure A0A0H3H403
Pocket Pocket 1
ColabFold model
FPocket 0.258 · Pocket 1
P2Rank 0.154 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 54 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
  • GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
  • GO:0032506 A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
338 415 ProSiteProfiles PS51724 SPOR domain profile.
338 415 InterPro IPR007730 Sporulation-like domain
61 75 MobiDBLite mobidb-lite consensus disorder prediction
124 221 MobiDBLite mobidb-lite consensus disorder prediction
99 120 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 60 MobiDBLite mobidb-lite consensus disorder prediction
340 413 Pfam PF05036 SPOR domain
340 413 InterPro IPR007730 Sporulation-like domain
1 97 MobiDBLite mobidb-lite consensus disorder prediction
53 73 Coils Coil Coil
1 424 Hamap MF_02021 Cell division protein DamX [damX].
1 424 InterPro IPR032899 Cell division protein DamX
340 404 SUPERFAMILY SSF110997 Sporulation related repeat
340 404 InterPro IPR036680 Sporulation-like domain superfamily
322 424 Gene3D G3DSA:3.30.70.1070 Sporulation related repeat
322 424 InterPro IPR036680 Sporulation-like domain superfamily
95 117 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
121 424 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 98 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
279 315 MobiDBLite mobidb-lite consensus disorder prediction
124 335 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H403
AlphaFold — — full sequence — Viewing
ColabFold KP13_00705
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer