Protein profile

KP13_00720

Para-aminobenzoate synthase glutamine amidotransferase component II

Genome: KpKP13

Gene: AHE42338.1 pabA Structure source: AlphaFold + ColabFold UniProt A0A0H3GU55
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Amino acids 187
Annotations 6
Features 24
PDB binders 3
Druggability 0.107

Overview

Basic information about this protein and its source genome.

Accession
KP13_00720
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42338.1 pabA
Status
annotated
Amino acids
187
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046820 Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. GO:0004049 Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0046656 The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. GO:0000162 The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. GO:0046654 The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
33.929
Human E-value
5.32e-11
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
56.186
DEG E-value
4.81e-76
Localization
Cytoplasmic
ColabFold pLDDT
97.98

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.107
Structure A0A0H3GU55
Pocket Pocket 2
P2Rank 0.257
Structure A0A0H3GU55
Pocket Pocket 1
ColabFold model
FPocket 0.182 · Pocket 3
P2Rank 0.12 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 694 / 4744 genomes with a hit
Normalized 0.146

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0046820 Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate.
  • GO:0004049 Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
  • GO:0046656 The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid.
  • GO:0000162 The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate.
  • GO:0046654 The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
2 185 CDD cd01743 GATase1_Anthranilate_Synthase
2 185 InterPro IPR006221 Anthranilate synthase/para-aminobenzoate synthase like domain
74 85 PRINTS PR00096 Glutamine amidotransferase superfamily signature
47 56 PRINTS PR00096 Glutamine amidotransferase superfamily signature
164 177 PRINTS PR00096 Glutamine amidotransferase superfamily signature
1 187 ProSiteProfiles PS51273 Glutamine amidotransferase type 1 domain profile.
1 186 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
1 186 InterPro IPR029062 Class I glutamine amidotransferase-like
74 90 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature
44 58 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature
1 187 Gene3D G3DSA:3.40.50.880 -
1 187 InterPro IPR029062 Class I glutamine amidotransferase-like
3 185 Pfam PF00117 Glutamine amidotransferase class-I
3 185 InterPro IPR017926 Glutamine amidotransferase
1 187 NCBIfam TIGR00566 glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
1 187 InterPro IPR006221 Anthranilate synthase/para-aminobenzoate synthase like domain
47 56 PRINTS PR00097 Anthranilate synthase component II signature
119 131 PRINTS PR00097 Anthranilate synthase component II signature
164 177 PRINTS PR00097 Anthranilate synthase component II signature
2 16 PRINTS PR00097 Anthranilate synthase component II signature
99 107 PRINTS PR00097 Anthranilate synthase component II signature
74 85 PRINTS PR00097 Anthranilate synthase component II signature
2 186 PANTHER PTHR43418 MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED
1 187 FunFam G3DSA:3.40.50.880:FF:000003 Anthranilate synthase component II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU55
AlphaFold — — full sequence — Viewing
ColabFold KP13_00720
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.96 0.096

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
IMP
1CE8
P0A6F1 348.2 Da LogP -2.15 TPSA 180.0 ✓ Ro5 ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…
ORN
1CE8
P0A6F1 132.2 Da LogP -0.86 TPSA 89.3 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)N)CN
POP
1GPM
P04079 176.0 Da LogP -2.08 TPSA 129.9 ✓ Ro5 ✓ Clean O[P@@](=O)([O-])O[P@@](=O)(O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.