Protein profile

KP13_31749

putative esterase

Genome: KpKP13

Gene: AHE42345.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWP4
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Amino acids 340
Annotations 2
Features 12
PDB binders 0
Druggability 0.984

Overview

Basic information about this protein and its source genome.

Accession
KP13_31749
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42345.1
Status
annotated
Amino acids
340
Structure source
AlphaFold + ColabFold
GO
GO:0047372 Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+. GO:0034338 Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.353
Human E-value
9.98e-15
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.984
Structure A0A0H3GWP4
Pocket Pocket 1
P2Rank 0.964
Structure A0A0H3GWP4
Pocket Pocket 1
ColabFold model
FPocket 0.99 · Pocket 1
P2Rank 0.953 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0047372 Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+.
  • GO:0034338 Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
240 281 ProSitePatterns PS01133 Uncharacterized protein family UPF0017 signature.
240 281 InterPro IPR000952 AB hydrolase 4, conserved site
21 334 PANTHER PTHR10794 ABHYDROLASE DOMAIN-CONTAINING PROTEIN
55 331 FunFam G3DSA:3.40.50.1820:FF:000080 Alpha/beta hydrolase
55 338 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
55 338 InterPro IPR029058 Alpha/Beta hydrolase fold
13 338 PIRSF PIRSF005211 Ab_hydro_YheT
13 338 InterPro IPR012020 AB hydrolase 4 family
37 333 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
37 333 InterPro IPR029058 Alpha/Beta hydrolase fold
74 314 Pfam PF00561 alpha/beta hydrolase fold
74 314 InterPro IPR000073 Alpha/beta hydrolase fold-1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWP4
AlphaFold — — full sequence — Viewing
ColabFold KP13_31749
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.984
16 0.835

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 30.35 0.934
2 1.8 0.034