Protein profile

KP13_00737

Sulfurtransferase tusD

Genome: KpKP13

Gene: AHE42354.1 tusD Structure source: AlphaFold + ColabFold UniProt A0A0H3GWN4
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Amino acids 128
Annotations 7
Features 11
PDB binders 0
Druggability 0.483

Overview

Basic information about this protein and its source genome.

Accession
KP13_00737
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42354.1 tusD
Status
annotated
Amino acids
128
Structure source
AlphaFold + ColabFold
EC
2.8.1.-
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0016783 Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:1990228 A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
78.125
DEG E-value
6.79e-71
Localization
Cytoplasmic
ColabFold pLDDT
97.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.483
Structure A0A0H3GWN4
Pocket Pocket 1
P2Rank 0.104
Structure A0A0H3GWN4
Pocket Pocket 1
ColabFold model
FPocket 0.205 · Pocket 1
P2Rank 0.149 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 123 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
  • GO:0016783 Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
  • GO:1990228 A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor).
  • GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule.
  • GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 128 SUPERFAMILY SSF75169 DsrEFH-like
1 128 InterPro IPR027396 DsrEFH-like
1 128 PANTHER PTHR34874 PROTEIN YCHN
1 128 Pfam PF02635 DsrE/DsrF-like family
1 128 InterPro IPR003787 Sulphur relay, DsrE/F-like
2 128 NCBIfam TIGR03012 sulfurtransferase complex subunit TusD
2 128 InterPro IPR017463 Sulphur relay, TusD/DsrE
1 128 Hamap MF_00390 Sulfurtransferase TusD [tusD].
1 128 InterPro IPR017463 Sulphur relay, TusD/DsrE
1 128 Gene3D G3DSA:3.40.1260.10 -
1 128 FunFam G3DSA:3.40.1260.10:FF:000001 Sulfurtransferase TusD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWN4
AlphaFold — — full sequence — Viewing
ColabFold KP13_00737
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.483

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.37 0.062