Protein profile

KP13_00738

Protein tusC

Genome: KpKP13

Gene: AHE42355.1 tusC Structure source: AlphaFold + ColabFold UniProt A0A0H3GYC6
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Amino acids 119
Annotations 2
Features 16
PDB binders 0
Druggability 0.461

Overview

Basic information about this protein and its source genome.

Accession
KP13_00738
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42355.1 tusC
Status
annotated
Amino acids
119
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
77.311
DEG E-value
1.46e-63
Localization
CytoplasmicMembrane
ColabFold pLDDT
96.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.461
Structure A0A0H3GYC6
Pocket Pocket 3
P2Rank 0.011
Structure A0A0H3GYC6
Pocket Pocket 1
ColabFold model
FPocket 0.027 · Pocket 3
P2Rank 0.015 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 121 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
12 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 119 PANTHER PTHR38780 PROTEIN TUSC
1 119 InterPro IPR017462 Sulphur relay, TusC/DsrF
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
4 119 NCBIfam TIGR03010 sulfurtransferase complex subunit TusC
4 119 InterPro IPR017462 Sulphur relay, TusC/DsrF
1 119 Gene3D G3DSA:3.40.1260.10 -
1 119 InterPro IPR027396 DsrEFH-like
17 119 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 119 Hamap MF_00389 Protein TusC [tusC].
1 119 InterPro IPR037450 Sulphur relay, TusC
1 119 SUPERFAMILY SSF75169 DsrEFH-like
4 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region
2 119 Pfam PF02635 DsrE/DsrF-like family
2 119 InterPro IPR003787 Sulphur relay, DsrE/F-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYC6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00738
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.461