Protein profile

KP13_00739

Protein tusB

Genome: KpKP13

Gene: AHE42356.1 tusB Structure source: AlphaFold + ColabFold UniProt A6TEY1
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Amino acids 95
Annotations 2
Features 11
PDB binders 0
Druggability 0.116

Overview

Basic information about this protein and its source genome.

Accession
KP13_00739
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42356.1 tusB
Status
annotated
Amino acids
95
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
60.0
DEG E-value
4.28e-38
Localization
Unknown
ColabFold pLDDT
97.7

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.116
Structure A6TEY1
Pocket Pocket 1
P2Rank
Structure A6TEY1
Pocket No pockets
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 74 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 95 Hamap MF_01564 Protein TusB [tusB].
1 95 InterPro IPR023526 Sulphur relay, TusB
8 90 Pfam PF04077 DsrH like protein
8 90 InterPro IPR007215 Sulphur relay, TusB/DsrH
1 95 Gene3D G3DSA:3.40.1260.10 -
1 95 InterPro IPR027396 DsrEFH-like
1 95 PANTHER PTHR37526 PROTEIN TUSB
1 95 InterPro IPR007215 Sulphur relay, TusB/DsrH
2 95 NCBIfam TIGR03011 sulfurtransferase complex subunit TusB
2 95 InterPro IPR007215 Sulphur relay, TusB/DsrH
1 95 SUPERFAMILY SSF75169 DsrEFH-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A6TEY1 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A6TEY1
AlphaFold — — full sequence — Viewing
ColabFold KP13_00739
ColabFold — — full sequence — Loaded