Protein profile

KP13_00747

Leader peptidase hopD

Genome: KpKP13

Gene: hopD AHE42364.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H3X2
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Amino acids 146
Annotations 2
Features 26
PDB binders 0
Druggability 0.544

Overview

Basic information about this protein and its source genome.

Accession
KP13_00747
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hopD AHE42364.1
Status
annotated
Amino acids
146
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004190 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
48.507
DEG E-value
9.38e-29
Localization
CytoplasmicMembrane
ColabFold pLDDT
74.78

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.544
Structure A0A0H3H3X2
Pocket Pocket 8
P2Rank 0.354
Structure A0A0H3H3X2
Pocket Pocket 1
ColabFold model
FPocket 0.95 · Pocket 4
P2Rank 0.432 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 52 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0004190 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
36 40 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
59 66 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
112 122 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
67 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
90 111 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 16 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 35 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
85 89 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
86 108 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
120 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
142 146 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 20 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature
3 20 InterPro IPR014032 Peptidase A24A, prepilin type IV, bacterial
60 70 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature
60 70 InterPro IPR014032 Peptidase A24A, prepilin type IV, bacterial
83 98 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature
83 98 InterPro IPR014032 Peptidase A24A, prepilin type IV, bacterial
71 82 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature
71 82 InterPro IPR014032 Peptidase A24A, prepilin type IV, bacterial
2 100 Pfam PF01478 Type IV leader peptidase family
2 100 InterPro IPR000045 Prepilin type IV endopeptidase, peptidase domain
41 58 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
123 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
40 59 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 135 PANTHER PTHR30487 TYPE 4 PREPILIN-LIKE PROTEINS LEADER PEPTIDE-PROCESSING ENZYME
1 110 Gene3D G3DSA:1.20.120.1220 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3X2
AlphaFold — — full sequence — Viewing
ColabFold KP13_00747
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.544
5 0.18
1 0.115
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.9 0.354
2 3.51 0.103
3 1.97 0.035
4 1.21 0.01