Protein profile

KP13_00751

50S ribosomal protein L23

Genome: KpKP13

Gene: AHE42368.1 rplW Structure source: AlphaFold + ColabFold UniProt A0A0H3H3W7
Export view
Amino acids 100
Annotations 4
Features 13
PDB binders 0
Druggability 0.398

Overview

Basic information about this protein and its source genome.

Accession
KP13_00751
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42368.1 rplW
Status
annotated
Amino acids
100
Structure source
AlphaFold + ColabFold
GO
GO:0019843 Binding to a ribosomal RNA. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.897
Human E-value
4.6e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
100.0
DEG E-value
3.1099999999999997e-68
Localization
Cytoplasmic
ColabFold pLDDT
89.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.398
Structure A0A0H3H3W7
Pocket Pocket 2
P2Rank 0.032
Structure A0A0H3H3W7
Pocket Pocket 1
ColabFold model
FPocket 0.367 · Pocket 2
P2Rank 0.021 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 233 / 4744 genomes with a hit
Normalized 0.049

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0019843 Binding to a ribosomal RNA.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
  • GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
9 95 Pfam PF00276 Ribosomal protein L23
9 95 InterPro IPR013025 Ribosomal protein L25/L23
7 95 PANTHER PTHR11620 60S RIBOSOMAL PROTEIN L23A
7 95 InterPro IPR013025 Ribosomal protein L25/L23
8 98 Hamap MF_01369_B 50S ribosomal protein L23 [rplW].
8 98 InterPro IPR013025 Ribosomal protein L25/L23
1 100 FunFam G3DSA:3.30.70.330:FF:000001 50S ribosomal protein L23
6 97 SUPERFAMILY SSF54189 Ribosomal proteins S24e, L23 and L15e
6 97 InterPro IPR012678 Ribosomal protein L23/L15e core domain superfamily
81 96 ProSitePatterns PS00050 Ribosomal protein L23 signature.
81 96 InterPro IPR001014 Ribosomal protein L23/L25, conserved site
1 100 Gene3D G3DSA:3.30.70.330 -
1 100 InterPro IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3W7
AlphaFold — — full sequence — Viewing
ColabFold KP13_00751
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.398
3 0.205