Protein profile

KP13_00757

50S ribosomal protein L29

Genome: KpKP13

Gene: AHE42373.1 rpmC Structure source: AlphaFold + ColabFold UniProt A0A0H3GWL2
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Amino acids 63
Annotations 4
Features 16
PDB binders 0
Druggability 0.216

Overview

Basic information about this protein and its source genome.

Accession
KP13_00757
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42373.1 rpmC
Status
annotated
Amino acids
63
Structure source
AlphaFold + ColabFold
GO
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0022625 The large subunit of a ribosome located in the cytosol.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
95.238
DEG E-value
2.9700000000000002e-37
Localization
Cytoplasmic
ColabFold pLDDT
87.98

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.216
Structure A0A0H3GWL2
Pocket Pocket 1
P2Rank
Structure A0A0H3GWL2
Pocket No pockets
ColabFold model
FPocket 0.398 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 378 / 4744 genomes with a hit
Normalized 0.08

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
  • GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
  • GO:0022625 The large subunit of a ribosome located in the cytosol.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 63 FunFam G3DSA:1.10.287.310:FF:000001 50S ribosomal protein L29
4 60 Pfam PF00831 Ribosomal L29 protein
4 60 InterPro IPR001854 Ribosomal protein L29/L35
5 60 NCBIfam TIGR00012 50S ribosomal protein L29
5 60 InterPro IPR001854 Ribosomal protein L29/L35
1 60 Hamap MF_00374 50S ribosomal protein L29 [rpmC].
1 60 InterPro IPR001854 Ribosomal protein L29/L35
1 61 SUPERFAMILY SSF46561 Ribosomal protein L29 (L29p)
1 61 InterPro IPR036049 Ribosomal protein L29/L35 superfamily
2 60 PANTHER PTHR10916 60S RIBOSOMAL PROTEIN L35/50S RIBOSOMAL PROTEIN L29
39 53 ProSitePatterns PS00579 Ribosomal protein L29 signature.
39 53 InterPro IPR018254 Ribosomal protein L29, conserved site
4 31 Coils Coil Coil
4 60 CDD cd00427 Ribosomal_L29_HIP
1 63 Gene3D G3DSA:1.10.287.310 -
1 63 InterPro IPR036049 Ribosomal protein L29/L35 superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWL2
AlphaFold — — full sequence — Viewing
ColabFold KP13_00757
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.216