Protein profile

KP13_00762

30S ribosomal protein S14

Genome: KpKP13

Gene: AHE42377.1 rpsN Structure source: AlphaFold + ColabFold UniProt A0A0H3GWK7
Export view
Amino acids 101
Annotations 6
Features 11
PDB binders 0
Druggability 0.453

Overview

Basic information about this protein and its source genome.

Accession
KP13_00762
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42377.1 rpsN
Status
annotated
Amino acids
101
Structure source
AlphaFold + ColabFold
GO
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0015935 The smaller of the two subunits of a ribosome. GO:0019843 Binding to a ribosomal RNA.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
36.275
Human E-value
3.41e-12
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
98.02
DEG E-value
3.83e-70
Localization
Cytoplasmic
ColabFold pLDDT
94.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.453
Structure A0A0H3GWK7
Pocket Pocket 2
P2Rank
Structure A0A0H3GWK7
Pocket No pockets
ColabFold model
FPocket 0.465 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 852 / 4744 genomes with a hit
Normalized 0.18

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
  • GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0015935 The smaller of the two subunits of a ribosome.
  • GO:0019843 Binding to a ribosomal RNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 101 PANTHER PTHR19836 30S RIBOSOMAL PROTEIN S14
1 101 InterPro IPR001209 Ribosomal protein S14
2 101 SUPERFAMILY SSF57716 Glucocorticoid receptor-like (DNA-binding domain)
47 100 Pfam PF00253 Ribosomal protein S14p/S29e
47 100 InterPro IPR001209 Ribosomal protein S14
63 85 ProSitePatterns PS00527 Ribosomal protein S14 signature.
63 85 InterPro IPR018271 Ribosomal protein S14, conserved site
1 91 FunFam G3DSA:1.10.287.1480:FF:000001 30S ribosomal protein S14
1 101 Hamap MF_00537 30S ribosomal protein S14 [rpsN].
1 101 InterPro IPR023036 Ribosomal protein S14, bacterial/plastid
1 91 Gene3D G3DSA:1.10.287.1480 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWK7
AlphaFold — — full sequence — Viewing
ColabFold KP13_00762
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.453