Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_00774
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: rplQ AHE42387.1
Status: annotated
Amino acids: 128
Structure source: AlphaFold + ColabFold

GO

GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0022625 The large subunit of a ribosome located in the cytosol.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 34.211
Human E-value: 8.04e-14
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 98.438
DEG E-value: 1.22e-88
Localization: Cytoplasmic
ColabFold pLDDT: 91.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.617

Structure A0A0H3GZ86

Pocket Pocket 1

P2Rank

Structure A0A0H3GZ86

Pocket No pockets

ColabFold model

FPocket 0.107 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 533 / 4744 genomes with a hit

Normalized 0.112

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
GO:0022625 The large subunit of a ribosome located in the cytosol.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
7	117	NCBIfam	TIGR00059	50S ribosomal protein L17
7	117	InterPro	IPR000456	Ribosomal protein L17
1	116	FunFam	G3DSA:3.90.1030.10:FF:000001	50S ribosomal protein L17
34	56	ProSitePatterns	PS01167	Ribosomal protein L17 signature.
34	56	InterPro	IPR000456	Ribosomal protein L17
5	116	Hamap	MF_01368	50S ribosomal protein L17 [rplQ].
5	116	InterPro	IPR000456	Ribosomal protein L17
20	116	Pfam	PF01196	Ribosomal protein L17
20	116	InterPro	IPR000456	Ribosomal protein L17
1	116	Gene3D	G3DSA:3.90.1030.10	Ribosomal protein L17
1	116	InterPro	IPR036373	Ribosomal protein L17 superfamily
1	118	SUPERFAMILY	SSF64263	Prokaryotic ribosomal protein L17
1	118	InterPro	IPR036373	Ribosomal protein L17 superfamily
1	125	PANTHER	PTHR14413	RIBOSOMAL PROTEIN L17
1	125	InterPro	IPR000456	Ribosomal protein L17

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GZ86	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_00774	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.617
4				0.037
2				0.0
8				0.0

KP13_00774