Protein profile

KP13_00784

DNA topoisomerase, type IA, Zn finger domain-containing protein

Genome: KpKP13

Gene: AHE42397.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ76
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Amino acids 180
Annotations 5
Features 16
PDB binders 0
Druggability 0.767

Overview

Basic information about this protein and its source genome.

Accession
KP13_00784
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42397.1
Status
annotated
Amino acids
180
Structure source
AlphaFold + ColabFold
GO
GO:0006265 The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0003916 Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0003917 Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.279
DEG E-value
8.22e-52
Localization
Cytoplasmic
ColabFold pLDDT
83.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.767
Structure A0A0H3GZ76
Pocket Pocket 1
P2Rank 0.02
Structure A0A0H3GZ76
Pocket Pocket 1
ColabFold model
FPocket 0.814 · Pocket 4
P2Rank 0.003 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 123 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006265 The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
  • GO:0003916 Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
  • GO:0003917 Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
  • GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
7 54 Gene3D G3DSA:3.30.65.10 Bacterial Topoisomerase I, domain 1
55 97 Gene3D G3DSA:3.30.65.10 Bacterial Topoisomerase I, domain 1
98 144 Gene3D G3DSA:3.30.65.10 Bacterial Topoisomerase I, domain 1
60 98 SUPERFAMILY SSF57783 Zinc beta-ribbon
61 98 Pfam PF01396 Topoisomerase DNA binding C4 zinc finger
61 98 InterPro IPR013498 DNA topoisomerase, type IA, zn finger
145 168 Pfam PF01396 Topoisomerase DNA binding C4 zinc finger
145 168 InterPro IPR013498 DNA topoisomerase, type IA, zn finger
105 142 Pfam PF01396 Topoisomerase DNA binding C4 zinc finger
105 142 InterPro IPR013498 DNA topoisomerase, type IA, zn finger
13 49 Pfam PF01396 Topoisomerase DNA binding C4 zinc finger
13 49 InterPro IPR013498 DNA topoisomerase, type IA, zn finger
4 52 PANTHER PTHR42785 DNA TOPOISOMERASE, TYPE IA, CORE
4 52 InterPro IPR000380 DNA topoisomerase, type IA
12 50 SUPERFAMILY SSF57783 Zinc beta-ribbon
7 53 FunFam G3DSA:3.30.65.10:FF:000005 Predicted DNA topoisomerase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ76
AlphaFold — — full sequence — Viewing
ColabFold KP13_00784
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.767
11 0.252
4 0.225