Protein profile

KP13_31775

Acriflavine resistance protein E

Genome: KpKP13

Gene: AHE42407.1 acrE Structure source: AlphaFold + ColabFold UniProt A0A0H3H3T2
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Amino acids 379
Annotations 3
Features 22
PDB binders 0
Druggability 0.913

Overview

Basic information about this protein and its source genome.

Accession
KP13_31775
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42407.1 acrE
Status
annotated
Amino acids
379
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
70.321
DEG E-value
6.6700000000000005e-167
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.913
Structure A0A0H3H3T2
Pocket Pocket 1
P2Rank 0.091
Structure A0A0H3H3T2
Pocket Pocket 1
ColabFold model
FPocket 0.6 · Pocket 1
P2Rank 0.055 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 143 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
7 374 PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
97 170 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
278 370 FunFam G3DSA:2.40.420.20:FF:000001 Efflux RND transporter periplasmic adaptor subunit
1 25 SignalP_EUK SignalP-noTM SignalP-noTM
62 206 Gene3D G3DSA:2.40.50.100 -
97 170 FunFam G3DSA:1.10.287.470:FF:000002 Efflux RND transporter periplasmic adaptor subunit
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 23 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
61 287 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
61 287 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
7 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
288 354 Pfam PF00529 Cation efflux system protein CusB domain 1
288 354 InterPro IPR043602 Cation efflux system protein CusB, domain 1
56 278 Gene3D G3DSA:2.40.30.170 -
38 369 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
38 369 InterPro IPR006143 RND efflux pump, membrane fusion protein
26 379 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
279 370 Gene3D G3DSA:2.40.420.20 -
50 294 SUPERFAMILY SSF111369 HlyD-like secretion proteins

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3T2
AlphaFold — — full sequence — Viewing
ColabFold KP13_31775
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.913

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.48 0.068