Protein profile

KP13_02951

DNA-binding protein fis

Genome: KpKP13

Gene: fis AHE42409.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTW9
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Amino acids 98
Annotations 5
Features 22
PDB binders 0
Druggability 0.305

Overview

Basic information about this protein and its source genome.

Accession
KP13_02951
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
fis AHE42409.1
Status
annotated
Amino acids
98
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
100.0
DEG E-value
1.5899999999999998e-68
Localization
Cytoplasmic
ColabFold pLDDT
91.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.305
Structure A0A0H3GTW9
Pocket Pocket 3
P2Rank
Structure A0A0H3GTW9
Pocket No pockets
ColabFold model
FPocket 0.475 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 166 / 4744 genomes with a hit
Normalized 0.035

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
55 95 Pfam PF02954 Bacterial regulatory protein, Fis family
55 95 InterPro IPR002197 DNA binding HTH domain, Fis-type
57 69 PRINTS PR01591 DNA-binding protein FIS signature
57 69 InterPro IPR005412 DNA-binding protein Fis
42 57 PRINTS PR01591 DNA-binding protein FIS signature
42 57 InterPro IPR005412 DNA-binding protein Fis
26 42 PRINTS PR01591 DNA-binding protein FIS signature
26 42 InterPro IPR005412 DNA-binding protein Fis
9 26 PRINTS PR01591 DNA-binding protein FIS signature
9 26 InterPro IPR005412 DNA-binding protein Fis
4 98 SUPERFAMILY SSF46689 Homeodomain-like
4 98 InterPro IPR009057 Homeobox-like domain superfamily
1 98 PANTHER PTHR47918 DNA-BINDING PROTEIN FIS
1 98 Gene3D G3DSA:1.10.10.60 -
1 98 FunFam G3DSA:1.10.10.60:FF:000006 DNA-binding protein Fis
1 98 PIRSF PIRSF002097 DNA-bp_Fis
1 98 InterPro IPR005412 DNA-binding protein Fis
78 98 PRINTS PR01590 FIS bacterial regulatory protein HTH signature
78 98 InterPro IPR002197 DNA binding HTH domain, Fis-type
61 78 PRINTS PR01590 FIS bacterial regulatory protein HTH signature
61 78 InterPro IPR002197 DNA binding HTH domain, Fis-type
1 98 Hamap MF_00166 DNA-binding protein Fis [fis].

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTW9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02951
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.305