Protein profile

KP13_02971

hypothetical protein

Genome: KpKP13

Gene: AHE42428.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWB0
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Amino acids 1265
Annotations 0
Features 14
PDB binders 0
Druggability 1

Overview

Basic information about this protein and its source genome.

Accession
KP13_02971
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42428.1
Status
annotated
Amino acids
1265
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 1
Structure A0A0H3GWB0
Pocket Pocket 107
P2Rank 0.999
Structure A0A0H3GWB0
Pocket Pocket 1
ColabFold model
FPocket 1 · Pocket 117
P2Rank 1 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 86 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
506 789 Pfam PF13116 Protein of unknown function
506 789 InterPro IPR025263 Domain of unknown function DUF3971
1 31 Phobius SIGNAL_PEPTIDE Signal peptide region
1009 1251 Pfam PF13502 AsmA-like C-terminal region
1009 1251 InterPro IPR032712 AsmA-like, C-terminal
2 1261 NCBIfam TIGR02099 YhdP family protein
2 1261 InterPro IPR011836 Conserved hypothetical protein CHP02099
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
32 1265 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 26 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 1265 PANTHER PTHR38690 PROTEASE-RELATED
1 1265 InterPro IPR011836 Conserved hypothetical protein CHP02099
27 31 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWB0
AlphaFold — — full sequence — Viewing
ColabFold KP13_02971
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
107 1.0
97 0.886
109 0.885

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 159.52 0.999
2 67.34 0.99
3 26.16 0.911
4 25.65 0.908
5 19.53 0.84