Protein profile

KP13_02975

p-hydroxybenzoic acid efflux pump subunit aaeA

Genome: KpKP13

Gene: AHE42432.1 aaeA Structure source: AlphaFold + ColabFold UniProt A0A0H3H3P2
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Amino acids 310
Annotations 3
Features 16
PDB binders 0
Druggability 0.086

Overview

Basic information about this protein and its source genome.

Accession
KP13_02975
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42432.1 aaeA
Status
annotated
Amino acids
310
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.086
Structure A0A0H3H3P2
Pocket Pocket 20
P2Rank 0.144
Structure A0A0H3H3P2
Pocket Pocket 1
ColabFold model
FPocket 0.252 · Pocket 21
P2Rank 0.043 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
46 216 SUPERFAMILY SSF111369 HlyD-like secretion proteins
124 144 Coils Coil Coil
12 32 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7 297 PANTHER PTHR30367 P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED
33 310 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
46 240 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
46 240 InterPro IPR006143 RND efflux pump, membrane fusion protein
170 295 Gene3D G3DSA:2.40.30.170 -
156 241 Pfam PF13437 HlyD family secretion protein
47 118 Gene3D G3DSA:2.40.50.100 -
1 310 Hamap MF_01544 p-hydroxybenzoic acid efflux pump subunit AaeA [aaeA].
1 310 InterPro IPR022871 Para-hydroxybenzoic acid efflux pump, subunit AaeA
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
48 94 Pfam PF13533 Biotin-lipoyl like
48 94 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3P2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02975
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer