Protein profile

KP13_03997

AFG1-family ATPase protein

Genome: KpKP13

Gene: AHE42451.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H3N2
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Amino acids 375
Annotations 3
Features 13
PDB binders 0
Druggability 0.278

Overview

Basic information about this protein and its source genome.

Accession
KP13_03997
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42451.1
Status
annotated
Amino acids
375
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
50.0
Human E-value
5.41e-12
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.278
Structure A0A0H3H3N2
Pocket Pocket 3
P2Rank 0.872
Structure A0A0H3H3N2
Pocket Pocket 1
ColabFold model
FPocket 0.958 · Pocket 20
P2Rank 0.931 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 132 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
5 371 Pfam PF03969 AFG1-like ATPase
5 371 InterPro IPR005654 ATPase, AFG1-like
10 364 NCBIfam NF040713 cell division protein ZapE
10 364 InterPro IPR005654 ATPase, AFG1-like
8 202 FunFam G3DSA:3.40.50.300:FF:001019 Cell division protein ZapE
68 209 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
68 209 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
64 215 Gene3D G3DSA:3.40.50.300 -
64 215 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
4 375 Hamap MF_01919 Cell division protein ZapE [zapE].
4 375 InterPro IPR030870 Cell division protein ZapE
3 372 PANTHER PTHR12169 ATPASE N2B
3 372 InterPro IPR005654 ATPase, AFG1-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3N2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03997
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.278
17 0.271

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.57 0.727
2 4.37 0.183