Protein profile

KP13_03215

Stringent starvation protein A

Genome: KpKP13

Gene: AHE42455.1 sspA Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ22
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Amino acids 212
Annotations 1
Features 23
PDB binders 4
Druggability 0.272

Overview

Basic information about this protein and its source genome.

Accession
KP13_03215
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42455.1 sspA
Status
annotated
Amino acids
212
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.237
Human E-value
3.12e-09
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.842
DEG E-value
4.4199999999999994e-54
Localization
Cytoplasmic
ColabFold pLDDT
94.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.272
Structure A0A0H3GZ22
Pocket Pocket 2
P2Rank 0.04
Structure A0A0H3GZ22
Pocket Pocket 1
ColabFold model
FPocket 0.101 · Pocket 6
P2Rank 0.047 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 154 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
89 193 FunFam G3DSA:1.20.1050.10:FF:000002 Stringent starvation protein A
102 194 Pfam PF00043 Glutathione S-transferase, C-terminal domain
102 194 InterPro IPR004046 Glutathione S-transferase, C-terminal
10 81 Pfam PF02798 Glutathione S-transferase, N-terminal domain
10 81 InterPro IPR004045 Glutathione S-transferase, N-terminal
9 87 ProSiteProfiles PS50404 Soluble glutathione S-transferase N-terminal domain profile.
9 87 InterPro IPR004045 Glutathione S-transferase, N-terminal
6 205 PANTHER PTHR43968 -
82 208 SUPERFAMILY SSF47616 GST C-terminal domain-like
82 208 InterPro IPR036282 Glutathione S-transferase, C-terminal domain superfamily
93 200 CDD cd03186 GST_C_SspA
93 200 InterPro IPR034342 Stringent starvation protein A, C-terminal
92 209 ProSiteProfiles PS50405 Soluble glutathione S-transferase C-terminal domain profile.
92 209 InterPro IPR010987 Glutathione S-transferase, C-terminal-like
11 83 CDD cd03059 GST_N_SspA
11 83 InterPro IPR034341 Stringent starvation protein A, N-terminal
7 90 SUPERFAMILY SSF52833 Thioredoxin-like
7 90 InterPro IPR036249 Thioredoxin-like superfamily
11 202 Gene3D G3DSA:3.40.30.10 Glutaredoxin
11 191 SFLD SFLDG00358 Main (cytGST)
11 191 SFLD SFLDS00019 Glutathione Transferase (cytosolic)
11 191 InterPro IPR040079 Glutathione transferase family
89 193 Gene3D G3DSA:1.20.1050.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ22
AlphaFold — — full sequence — Viewing
ColabFold KP13_03215
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.272

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.44 0.019

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
4NM
5AGY
I1MJ34 170.2 Da LogP 1.92 TPSA 40.3 ✓ Ro5 ✓ Clean c1cc(ccc1CS)[N+](=O)O
G4P
5U51
Q5NHJ6 603.2 Da LogP -2.22 TPSA 345.6 3 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…
GSH
5J4U
B9I0G5 307.3 Da LogP -2.21 TPSA 158.8 1 viol. ✓ Clean C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N
GTB
5AGY
I1MJ34 442.5 Da LogP -0.29 TPSA 202.0 ✓ Ro5 ✓ Clean c1cc(ccc1CSC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H]…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.