Protein profile

KP13_03226

Enhancing lycopene biosynthesis protein 2

Genome: KpKP13

Gene: elbB AHE42467.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTT8
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Amino acids 217
Annotations 1
Features 9
PDB binders 0
Druggability 0.269

Overview

Basic information about this protein and its source genome.

Accession
KP13_03226
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
elbB AHE42467.1
Status
annotated
Amino acids
217
Structure source
AlphaFold + ColabFold
GO
GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
54.808
Human E-value
8.9e-31
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
98.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.269
Structure A0A0H3GTT8
Pocket Pocket 4
P2Rank 0.17
Structure A0A0H3GTT8
Pocket Pocket 1
ColabFold model
FPocket 0.196 · Pocket 9
P2Rank 0.149 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 126 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 215 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
1 215 InterPro IPR029062 Class I glutamine amidotransferase-like
4 215 CDD cd03133 GATase1_ES1
1 216 PIRSF PIRSF006320 Elb2
1 216 InterPro IPR026041 Glyoxalase ElbB
1 217 Gene3D G3DSA:3.40.50.880 -
1 217 InterPro IPR029062 Class I glutamine amidotransferase-like
1 217 FunFam G3DSA:3.40.50.880:FF:000032 Glyoxalase
2 216 PANTHER PTHR10224 ES1 PROTEIN HOMOLOG, MITOCHONDRIAL

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTT8
AlphaFold — — full sequence — Viewing
ColabFold KP13_03226
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.269

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.34 0.18