Protein profile

KP13_03228

Phosphocarrier protein NPr

Genome: KpKP13

Gene: ptsO AHE42469.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW82
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Amino acids 90
Annotations 2
Features 23
PDB binders 0
Druggability 0.444

Overview

Basic information about this protein and its source genome.

Accession
KP13_03228
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ptsO AHE42469.1
Status
annotated
Amino acids
90
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
58.427
DEG E-value
2.66e-35
Localization
Cytoplasmic
ColabFold pLDDT
87.99

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.444
Structure A0A0H3GW82
Pocket Pocket 3
P2Rank
Structure A0A0H3GW82
Pocket No pockets
ColabFold model
FPocket 0.251 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
14 21 ProSitePatterns PS00369 PTS HPR domain histidine phosphorylation site signature.
14 21 InterPro IPR001020 Phosphotransferase system, HPr histidine phosphorylation site
41 56 ProSitePatterns PS00589 PTS HPR domain serine phosphorylation site signature.
41 56 InterPro IPR002114 Phosphotransferase system, HPr serine phosphorylation site
4 84 NCBIfam TIGR01003 HPr family phosphocarrier protein
4 84 InterPro IPR000032 Phosphocarrier protein HPr-like
55 72 PRINTS PR00107 Phosphocarrier protein signature
55 72 InterPro IPR000032 Phosphocarrier protein HPr-like
40 55 PRINTS PR00107 Phosphocarrier protein signature
40 55 InterPro IPR000032 Phosphocarrier protein HPr-like
14 30 PRINTS PR00107 Phosphocarrier protein signature
14 30 InterPro IPR000032 Phosphocarrier protein HPr-like
2 90 ProSiteProfiles PS51350 PTS HPR domain profile.
2 90 InterPro IPR000032 Phosphocarrier protein HPr-like
1 85 Gene3D G3DSA:3.30.1340.10 -
1 85 InterPro IPR035895 HPr-like superfamily
4 84 Pfam PF00381 PTS HPr component phosphorylation site
4 90 SUPERFAMILY SSF55594 HPr-like
4 90 InterPro IPR035895 HPr-like superfamily
1 89 PANTHER PTHR33705 PHOSPHOCARRIER PROTEIN HPR
6 83 CDD cd00367 PTS-HPr_like
6 83 InterPro IPR000032 Phosphocarrier protein HPr-like
1 85 FunFam G3DSA:3.30.1340.10:FF:000002 PTS phosphocarrier protein NPr

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW82
AlphaFold — — full sequence — Viewing
ColabFold KP13_03228
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.444