Protein profile

KP13_03231

putative sigma(54) modulation protein

Genome: KpKP13

Gene: AHE42472.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTT3
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Amino acids 95
Annotations 4
Features 11
PDB binders 0
Druggability 0.472

Overview

Basic information about this protein and its source genome.

Accession
KP13_03231
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42472.1
Status
annotated
Amino acids
95
Structure source
AlphaFold + ColabFold
GO
GO:0044238 The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. GO:0022627 The small subunit of a ribosome located in the cytosol. GO:0043024 Binding to a small ribosomal subunit. GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
48.387
DEG E-value
4.66e-26
Localization
Cytoplasmic
ColabFold pLDDT
94.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.472
Structure A0A0H3GTT3
Pocket Pocket 1
P2Rank
Structure A0A0H3GTT3
Pocket No pockets
ColabFold model
FPocket 0.456 · Pocket 1
P2Rank 0.002 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 134 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0044238 The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
  • GO:0022627 The small subunit of a ribosome located in the cytosol.
  • GO:0043024 Binding to a small ribosomal subunit.
  • GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
3 93 Pfam PF02482 Sigma 54 modulation protein / S30EA ribosomal protein
3 93 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
2 91 CDD cd00552 RaiA
2 91 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
1 95 NCBIfam TIGR00741 ribosome-associated translation inhibitor RaiA
1 95 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
1 95 Gene3D G3DSA:3.30.160.100 -
1 95 InterPro IPR036567 Ribosome hibernation promotion factor-like
1 95 FunFam G3DSA:3.30.160.100:FF:000001 Ribosome hibernation promoting factor
1 95 PANTHER PTHR33231 30S RIBOSOMAL PROTEIN
1 95 SUPERFAMILY SSF69754 Ribosome binding protein Y (YfiA homologue)

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTT3
AlphaFold — — full sequence — Viewing
ColabFold KP13_03231
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.472