Protein profile

KP13_31622

Lipopolysaccharide export system protein lptA

Genome: KpKP13

Gene: lptA AHE42475.1 Structure source: Experimental + AlphaFold + ColabFold UniProt A6TEL9
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Amino acids 181
Annotations 3
Features 17
PDB binders 0
Druggability 0.465

Overview

Basic information about this protein and its source genome.

Accession
KP13_31622
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
lptA AHE42475.1
Status
annotated
Amino acids
181
Structure source
Experimental + AlphaFold + ColabFold
GO
GO:0001530 Binding to a lipopolysaccharide. GO:0015920 The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.152
DEG E-value
9.39e-111
Localization
Unknown
ColabFold pLDDT
84.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.465
Structure A6TEL9
Pocket Pocket 2
P2Rank
Structure A6TEL9
Pocket No pockets
ColabFold model
FPocket 0.468 · Pocket 3
P2Rank 0.039 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 130 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0001530 Binding to a lipopolysaccharide.
  • GO:0015920 The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
28 164 FunFam G3DSA:2.60.450.10:FF:000002 Lipopolysaccharide export system protein LptA
7 167 Hamap MF_01914 Lipopolysaccharide export system protein LptA [lptA].
7 167 InterPro IPR014340 Lipopolysaccharide export system protein LptA
24 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 29 SignalP_EUK SignalP-noTM SignalP-noTM
37 149 Pfam PF03968 LptA/(LptD N-terminal domain) LPS transport protein
37 149 InterPro IPR005653 Organic solvent tolerance-like, N-terminal
1 27 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
28 181 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 179 PANTHER PTHR36504 LIPOPOLYSACCHARIDE EXPORT SYSTEM PROTEIN LPTA
1 27 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
29 164 Gene3D G3DSA:2.60.450.10 Lipopolysaccharide (LPS) transport protein A like domain
27 166 NCBIfam TIGR03002 lipopolysaccharide transport periplasmic protein LptA
27 166 InterPro IPR014340 Lipopolysaccharide export system protein LptA
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7ZAX
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
AlphaFold AF_A6TEL9
AlphaFold — — full sequence — Loaded
ColabFold KP13_31622
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.38 0.558
2 1.91 0.039
3 1.91 0.039
4 1.46 0.02
5 1.4 0.017