Protein profile

KP13_03236

3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Genome: KpKP13

Gene: kdsC AHE42477.1 Structure source: Experimental + ColabFold UniProt A0A0H3GTS8
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Amino acids 188
Annotations 6
Features 17
PDB binders 0
Druggability 0.287

Overview

Basic information about this protein and its source genome.

Accession
KP13_03236
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
kdsC AHE42477.1
Status
annotated
Amino acids
188
Structure source
Experimental + ColabFold
EC
3.1.3.45
GO
GO:0016788 Catalysis of the hydrolysis of any ester bond. GO:0019143 Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. GO:0046872 Binding to a metal ion. GO:0008781 Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.335
Human E-value
1.04e-18
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
57.062
DEG E-value
7.93e-64
Localization
Cytoplasmic
ColabFold pLDDT
96.58

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.287
Structure 7T35
Pocket Pocket 5
P2Rank 0.021
Structure 7T35
Pocket Pocket 1
ColabFold model
FPocket 0.552 · Pocket 1
P2Rank 0.124 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 144 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0016788 Catalysis of the hydrolysis of any ester bond.
  • GO:0019143 Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate.
  • GO:0046872 Binding to a metal ion.
  • GO:0008781 Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
24 180 PANTHER PTHR21485 HAD SUPERFAMILY MEMBERS CMAS AND KDSC
22 181 SUPERFAMILY SSF56784 HAD-like
22 181 InterPro IPR036412 HAD-like superfamily
7 188 FunFam G3DSA:3.40.50.1000:FF:000029 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
26 178 NCBIfam TIGR01670 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family
26 178 InterPro IPR010023 KdsC family
1 188 Gene3D G3DSA:3.40.50.1000 -
1 188 InterPro IPR023214 HAD superfamily
94 162 Pfam PF08282 haloacid dehalogenase-like hydrolase
27 142 NCBIfam TIGR01662 HAD-IIIA family hydrolase
27 142 InterPro IPR006549 HAD-superfamily hydrolase,subfamily IIIA
26 171 CDD cd01630 HAD_KDO-like
21 181 SFLD SFLDG01138 C1.6.2: Deoxy-d-mannose-octulosonate 8-phosphate Phosphatase Like
21 181 InterPro IPR010023 KdsC family
21 181 SFLD SFLDG01136 C1.6: Phosphoserine Phosphatase Like
13 188 PIRSF PIRSF006118 KDO8-P_Ptase
13 188 InterPro IPR010023 KdsC family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7T35
X-ray 2.65 Å A
100.0% 1-188
PDBe RCSB PDBj File
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ColabFold KP13_03236
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.287
1 0.265

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.5 0.021
2 1.23 0.011