Protein profile

KP13_01123

putative phospholipid ABC transporter-binding protein mlaB

Genome: KpKP13

Gene: AHE42483.1 mlaB Structure source: AlphaFold + ColabFold UniProt A0A0H3GW69

Export view

Amino acids 95

Annotations 0

Features 11

PDB binders 0

Druggability 0.508

Overview

Basic information about this protein and its source genome.

Accession: KP13_01123
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE42483.1 mlaB
Status: annotated
Amino acids: 95
Structure source: AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 54.737
DEG E-value: 3.7e-27
Localization: Unknown
ColabFold pLDDT: 90.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.508

Structure A0A0H3GW69

Pocket Pocket 1

P2Rank

Structure A0A0H3GW69

Pocket No pockets

ColabFold model

FPocket 0.572 · Pocket 2

P2Rank 0.019 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 71 / 4744 genomes with a hit

Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
4	90	CDD	cd07043	STAS_anti-anti-sigma_factors
4	93	Gene3D	G3DSA:3.30.750.24	STAS domain
4	93	InterPro	IPR036513	STAS domain superfamily
4	90	SUPERFAMILY	SSF52091	SpoIIaa-like
4	90	InterPro	IPR036513	STAS domain superfamily
14	95	ProSiteProfiles	PS50801	STAS domain profile.
14	95	InterPro	IPR002645	STAS domain
1	93	PANTHER	PTHR35849	BLR2341 PROTEIN
14	90	Pfam	PF13466	STAS domain
14	90	InterPro	IPR002645	STAS domain
4	94	NCBIfam	NF033618	lipid asymmetry maintenance protein MlaB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GW69	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_01123	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.008
2				0.0
4				0.0
7				0.0

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.572
3				0.505

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Sticks	Spheres	Surfaces	Score	Probability	Labels	Zoom	Positions
1				1.28	0.013

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

No PDB ligands found through similar proteins.

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Ligand	UniProt (homolog)	pchembl	MW · LogP · TPSA	Lipinski	PAINS	SMILES
FOM	P64602	—	183.1 Da LogP -0.60 TPSA 98.1	✓ Ro5	✓ Clean	`C(CN(C=O)O)CP(=O)(O)O`

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.