Protein profile

KP13_01113

Transcription elongation factor greA

Genome: KpKP13

Gene: AHE42493.1 greA Structure source: AlphaFold + ColabFold UniProt A0A0H3GW62
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Amino acids 153
Annotations 5
Features 25
PDB binders 0
Druggability 0.372

Overview

Basic information about this protein and its source genome.

Accession
KP13_01113
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42493.1 greA
Status
annotated
Amino acids
153
Structure source
AlphaFold + ColabFold
GO
GO:0032784 Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. GO:0070063 Binding to an RNA polymerase molecule or complex. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003746 Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.316
DEG E-value
4.2000000000000004e-48
Localization
Cytoplasmic
ColabFold pLDDT
95.3

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.372
Structure A0A0H3GW62
Pocket Pocket 1
P2Rank
Structure A0A0H3GW62
Pocket No pockets
ColabFold model
FPocket 0.506 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 337 / 4744 genomes with a hit
Normalized 0.071

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0032784 Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
  • GO:0070063 Binding to an RNA polymerase molecule or complex.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003746 Functions in chain elongation during polypeptide synthesis at the ribosome.
  • GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
116 132 ProSitePatterns PS00830 Prokaryotic transcription elongation factors signature 2.
116 132 InterPro IPR018151 Transcription elongation factor, GreA/GreB, conserved site
1 71 FunFam G3DSA:1.10.287.180:FF:000001 Transcription elongation factor GreA
1 69 Pfam PF03449 Transcription elongation factor, N-terminal
1 69 InterPro IPR022691 Transcription elongation factor, GreA/GreB, N-terminal
78 152 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term
78 152 InterPro IPR001437 Transcription elongation factor, GreA/GreB, C-terminal
76 153 FunFam G3DSA:3.10.50.30:FF:000001 Transcription elongation factor GreA
1 73 SUPERFAMILY SSF46557 GreA transcript cleavage protein, N-terminal domain
1 73 InterPro IPR036805 Transcription elongation factor, GreA/GreB, N-terminal domain superfamily
12 43 ProSitePatterns PS00829 Prokaryotic transcription elongation factors signature 1.
12 43 InterPro IPR018151 Transcription elongation factor, GreA/GreB, conserved site
1 152 PANTHER PTHR30437 TRANSCRIPTION ELONGATION FACTOR GREA
1 152 InterPro IPR023459 Transcription elongation factor GreA/GreB family
1 70 Gene3D G3DSA:1.10.287.180 -
1 70 InterPro IPR036805 Transcription elongation factor, GreA/GreB, N-terminal domain superfamily
1 153 PIRSF PIRSF006092 GreA_GreB
1 153 InterPro IPR023459 Transcription elongation factor GreA/GreB family
76 152 SUPERFAMILY SSF54534 FKBP-like
1 151 Hamap MF_00105 Transcription elongation factor GreA [greA].
1 151 InterPro IPR028624 Transcription elongation factor GreA/GreB
71 153 Gene3D G3DSA:3.10.50.30 -
71 153 InterPro IPR036953 Transcription elongation factor GreA/GreB, C-terminal domain superfamily
1 151 NCBIfam TIGR01462 transcription elongation factor GreA
1 151 InterPro IPR006359 Transcription elongation factor GreA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW62
AlphaFold — — full sequence — Viewing
ColabFold KP13_01113
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.372