Protein profile

KP13_01107

Protein-export membrane protein secG

Genome: KpKP13

Gene: secG AHE42499.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GY13
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Amino acids 109
Annotations 6
Features 24
PDB binders 0
Druggability 0.783

Overview

Basic information about this protein and its source genome.

Accession
KP13_01107
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
secG AHE42499.1
Status
annotated
Amino acids
109
Structure source
AlphaFold + ColabFold
GO
GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015450 Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
89.091
DEG E-value
6.35e-67
Localization
CytoplasmicMembrane
ColabFold pLDDT
65.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.783
Structure A0A0H3GY13
Pocket Pocket 5
P2Rank
Structure A0A0H3GY13
Pocket No pockets
ColabFold model
FPocket 0.86 · Pocket 10
P2Rank 0.007 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 161 / 4744 genomes with a hit
Normalized 0.034

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015450 Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
  • GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
51 70 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
71 109 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
81 109 MobiDBLite mobidb-lite consensus disorder prediction
3 74 NCBIfam TIGR00810 preprotein translocase subunit SecG
3 74 InterPro IPR004692 Preprotein translocase SecG subunit
1 101 PANTHER PTHR34182 PROTEIN-EXPORT MEMBRANE PROTEIN SECG
1 101 InterPro IPR004692 Preprotein translocase SecG subunit
51 73 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
38 54 PRINTS PR01651 Protein-export SecG membrane protein signature
38 54 InterPro IPR004692 Preprotein translocase SecG subunit
54 76 PRINTS PR01651 Protein-export SecG membrane protein signature
54 76 InterPro IPR004692 Preprotein translocase SecG subunit
3 23 PRINTS PR01651 Protein-export SecG membrane protein signature
3 23 InterPro IPR004692 Preprotein translocase SecG subunit
23 37 PRINTS PR01651 Protein-export SecG membrane protein signature
23 37 InterPro IPR004692 Preprotein translocase SecG subunit
23 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
28 50 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
5 72 Pfam PF03840 Preprotein translocase SecG subunit
5 72 InterPro IPR004692 Preprotein translocase SecG subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GY13
AlphaFold — — full sequence — Viewing
ColabFold KP13_01107
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.783
3 0.64